Document Detail

Mouse models for Down syndrome-associated developmental cognitive disabilities.
MedLine Citation:
PMID:  21865664     Owner:  NLM     Status:  MEDLINE    
Down syndrome (DS) is mainly caused by the presence of an extra copy of human chromosome 21 (Hsa21) and is a leading genetic cause for developmental cognitive disabilities in humans. The mouse is a premier model organism for DS because the regions on Hsa21 are syntenically conserved with three regions in the mouse genome, which are located on mouse chromosome 10 (Mmu10), Mmu16 and Mmu17. With the advance of chromosomal manipulation technologies, new mouse mutants have been generated to mimic DS at both the genotypic and phenotypic levels. Further mouse-based molecular genetic studies in the future may lead to the unraveling of the mechanisms underlying DS-associated developmental cognitive disabilities, which would lay the groundwork for developing effective treatments for this phenotypic manifestation. In this review, we will discuss recent progress and future challenges in modeling DS-associated developmental cognitive disability in mice with an emphasis on hippocampus-related phenotypes.
Chunhong Liu; Pavel V Belichenko; Li Zhang; Dawei Fu; Alexander M Kleschevnikov; Antonio Baldini; Stylianos E Antonarakis; William C Mobley; Y Eugene Yu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-08-25
Journal Detail:
Title:  Developmental neuroscience     Volume:  33     ISSN:  1421-9859     ISO Abbreviation:  Dev. Neurosci.     Publication Date:  2011  
Date Detail:
Created Date:  2011-12-13     Completed Date:  2012-04-16     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7809375     Medline TA:  Dev Neurosci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  404-13     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Children's Guild Foundation Down Syndrome Research Program and Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
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MeSH Terms
Cognition Disorders / etiology*,  genetics,  physiopathology
Developmental Disabilities / etiology*,  genetics,  physiopathology
Disease Models, Animal
Down Syndrome / complications*,  genetics,  physiopathology
Grant Support

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