Document Detail


A mouse model for fetal maternal stem cell transfer during ischemic cardiac injury.
MedLine Citation:
PMID:  22883609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fetal cells enter the maternal circulation during pregnancies and can persist in blood and tissues for decades, creating a state of physiologic microchimerism. Microchimerism refers to acquisition of cells from another individual and can be due to bidirectional cell traffic between mother and fetus during pregnancy. Peripartum cardiomyopathy, a rare cardiac disorder associated with high mortality rates has the highest recovery rate amongst all etiologies of heart failure although the reason is unknown. Collectively, these observations led us to hypothesize that fetal cells enter the maternal circulation and may be recruited to the sites of myocardial disease or injury. The ability to genetically modify mice makes them an ideal system for studying the phenomenon of microchimerism in cardiac disease. Described here is a mouse model for ischemic cardiac injury during pregnancy designed to study microchimerism. Wild-type virgin female mice mated with eGFP male mice underwent ligation of the left anterior descending artery to induce a myocardial infarction at gestation day 12. We demonstrate the selective homing of eGFP cells to the site of cardiac injury without such homing to noninjured tissues suggesting the presence of precise signals sensed by fetal cells enabling them to target diseased myocardium specifically.
Authors:
Rina J Kara; Paola Bolli; Iwao Matsunaga; Omar Tanweer; Perry Altman; Hina W Chaudhry
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-06-18
Journal Detail:
Title:  Clinical and translational science     Volume:  5     ISSN:  1752-8062     ISO Abbreviation:  Clin Transl Sci     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-13     Completed Date:  2013-04-10     Revised Date:  2013-08-12    
Medline Journal Info:
Nlm Unique ID:  101474067     Medline TA:  Clin Transl Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  321-8     Citation Subset:  IM    
Copyright Information:
© 2012 Wiley Periodicals, Inc.
Affiliation:
Mount Sinai School of Medicine, Cardiovascular Institute, New York, New York, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal*
Female
Fetal Stem Cells / cytology*
Flow Cytometry
Fluorescent Antibody Technique
Green Fluorescent Proteins / blood
Male
Maternal-Fetal Exchange*
Mice
Mice, Inbred C57BL
Myocardial Ischemia / therapy*
Pregnancy
Pregnancy Complications, Cardiovascular / therapy*
Stem Cell Transplantation*
Grant Support
ID/Acronym/Agency:
R01 HL088255/HL/NHLBI NIH HHS; R01-HL 088255/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/enhanced green fluorescent protein; 147336-22-9/Green Fluorescent Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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