| A mouse model characterizing features of vascular dementia with hippocampal atrophy. | |
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MedLine Citation:
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PMID: 20448204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: We have previously described effects of chronic cerebral hypoperfusion in mice with bilateral common carotid artery stenosis (BCAS) using microcoils for 30 days. These mice specifically exhibit working memory deficits attributable to frontal-subcortical circuit damage without apparent gray matter changes, indicating similarities with subcortical ischemic vascular dementia. However, as subcortical ischemic vascular dementia progresses over time, the longer-term effects that characterize the mouse model are not known. METHODS: Comprehensive behavioral test batteries and histological examinations were performed in mice subjected to BCAS for up to 8 months. Laser speckle flowmetry and (18)F-fluorodeoxyglucose positron emission tomography were performed to assess cerebral blood flow and metabolism at several time points. RESULTS: At 2 hours after BCAS, cerebral blood flow in the cerebral cortex temporarily decreased to as much as 60% to 70% of the control value but gradually recovered to >80% at 1 to 3 months. At 5 to 6 months after BCAS, reference and working memory were impaired as demonstrated by the Barnes and radial arm maze tests, respectively. Furthermore, (18)F-fluorodeoxyglucose positron emission tomography demonstrated that hippocampal glucose utilization was impaired at 6 months after BCAS. Consistent with these behavioral and metabolic abnormalities, histological analyses demonstrated hippocampal atrophy with pyknotic and apoptotic cells at 8 months after BCAS. CONCLUSIONS: These results suggest that the longer-term BCAS model replicates advanced stages of subcortical ischemic vascular dementia when hippocampal neuronal loss becomes significant. |
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Authors:
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Keiko Nishio; Masafumi Ihara; Nobuyuki Yamasaki; Raj N Kalaria; Takakuni Maki; Youshi Fujita; Hidefumi Ito; Naoya Oishi; Hidenao Fukuyama; Tsuyoshi Miyakawa; Ryosuke Takahashi; Hidekazu Tomimoto |
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Publication Detail:
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Type: Journal Article Date: 2010-05-06 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 41 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-25 Completed Date: 2010-06-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 1278-84 Citation Subset: IM |
Affiliation:
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Department of Neurology, Faculty of Medicine, Kyoto University, Sakyo-Ku, Kyoto 606-8507 Japan. ihara@kuhp.kyoto-u.ac.jp. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis Atrophy Behavior, Animal* Carotid Artery, Common / physiopathology, radiography Carotid Stenosis* / complications, physiopathology, radiography Cerebrovascular Circulation Dementia, Vascular* / etiology, physiopathology, radiography Disease Models, Animal Fluorodeoxyglucose F18 / pharmacology Hippocampus* / physiopathology, radiography Male Maze Learning* Mice Positron-Emission Tomography* Radiopharmaceuticals / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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