| Mott cell (Russell bodies) Barrett's oesophagitis. | |
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MedLine Citation:
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PMID: 16277029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The first case of Barrett's oesophagus with chronic inflammation having predominantly (> 50%) Mott cells, i.e. plasma cells with stored immunoglobulins, known as Russell bodies, is reported. Biopsies from two oesophagoscopies revealed similar changes, suggesting that the predominance of Mott cells is not a fortuitous event but a more long-lasting microscopic process. Periodic acid-Schiff (PAS) stain ruled out Candida albicans and immunostains, plasma cell neoplasia. Mott cells were not present in biopsies from the gastric mucosa or the urinary bladder, suggesting that this phenomenon was not widespread but localized to the Barrett's mucosa. The retention of immunoglobulins (Russell bodies) suggests that the mechanism of protein transport in those plasma cells is incompetent, and that the proteins are neither degraded nor secreted, but remain stored in dilated cisternae. Increased awareness of the existence of this subgroup of Barrett's oesophagitis may result in similar cases being reported in the future. |
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Authors:
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C A Rubio |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: In vivo (Athens, Greece) Volume: 19 ISSN: 0258-851X ISO Abbreviation: In Vivo Publication Date: 2005 Nov-Dec |
Date Detail:
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Created Date: 2005-11-09 Completed Date: 2005-12-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8806809 Medline TA: In Vivo Country: Greece |
Other Details:
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Languages: eng Pagination: 1097-100 Citation Subset: IM |
Affiliation:
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Gastrointestinal and Liver Pathology Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden. Carlos.Rubio@onkpat.ki.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged, 80 and over Alcian Blue / metabolism Antigens, CD / metabolism Antigens, CD38 / metabolism Azure Stains / metabolism Barrett Esophagus / pathology*, surgery Chronic Disease Esophagoscopy Humans Hydrogen-Ion Concentration Immunoglobulins / metabolism Inflammation / pathology Intestinal Mucosa / pathology* Male Microscopy, Fluorescence Periodic Acid-Schiff Reaction Plasma Cells / pathology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Azure Stains; 0/Immunoglobulins; 12040-44-7/Alcian Blue; EC 3.2.2.5/Antigens, CD38 |
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