Document Detail


Motor unit number index (MUNIX) versus motor unit number estimation (MUNE): A direct comparison in a longitudinal study of ALS patients.
MedLine Citation:
PMID:  22321299     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate how the motor unit number index (MUNIX) is related to high-density motor unit number estimation (HD-MUNE) in healthy controls and patients with amyotrophic lateral sclerosis (ALS). METHODS: Both MUNIX and HD-MUNE were performed on the thenar muscles in 18 ALS patients and 24 healthy controls. Patients were measured at baseline, within 2weeks, and after 4 and 8months. Clinical evaluation included Medical Research Council (MRC) scale and the ALS functional rating scale (ALSFRS). RESULTS: There was a significant positive correlation between MUNE and MUNIX values in ALS patients (r=0.49 at baseline; r=0.56 at 4months; r=0.56 at 8months, all p<0.05), but not in healthy controls. After 8months, both MUNE and MUNIX values of the ALS patients decreased significantly more compared to MRC scale, ALS functional rating scale (ALSFRS) and compound muscle action potential (CMAP) (p<0.05). There was no significant difference in relative decline of MUNIX and HD-MUNE values. CONCLUSIONS: In ALS patients, MUNIX and HD-MUNE are significantly correlated. MUNIX has an almost equivalent potential in detecting motor neuron loss compared to HD-MUNE. SIGNIFICANCE: MUNIX could serve as a reliable and sensitive marker for monitoring disease progression in ALS.
Authors:
Werner A Boekestein; Helenius J Schelhaas; Michel J A M van Putten; Dick F Stegeman; Machiel J Zwarts; Johannes P van Dijk
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-7
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  -     ISSN:  1872-8952     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Donders Institute for Brain, Cognition and Behavior, Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Department of Neurology and Clinical Neurophysiology, Medisch Spectrum Twente, and MIRA-Institute for Biomedical Technology and Technical Medicine, University of Twente, The Netherlands.
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