Document Detail


Motor root conduction block in the lewis-sumner syndrome.
MedLine Citation:
PMID:  21321496     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: : The Lewis-Sumner syndrome (LSS) is a rare immune-mediated peripheral nerve disorder presenting with asymmetric upper limb sensory complaints and motor weakness. Asian patients with LSS have not been reported in the English literature.
METHODS: : Three Asian patients with features of LSS were prospectively studied.
RESULTS: : Our patients tended to older, female, and have involvement of the upper limbs exclusively than those in the West. They have a markedly longer disease duration before a diagnosis was made, which could also be the result of difficulty in eliciting motor root conduction block as a sign of proximal demyelination as observed in every patient. Pain is a universal feature as is sensory nerve conduction abnormality. None responded to immunotherapy, but disease stabilization was observed over the chronic course.
CONCLUSIONS: : Although rare, these unique observations in Asian patients with LSS differ from those reported in Western literature. The presence of motor root conduction block demonstrated for the first time is instrumental in establishing a diagnosis.
Authors:
Yew Long Lo; Yang-Fang Dan; Yam-Eng Tan; Teng-Hee Leoh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical neuromuscular disease     Volume:  12     ISSN:  1537-1611     ISO Abbreviation:  J Clin Neuromuscul Dis     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100887391     Medline TA:  J Clin Neuromuscul Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  158-62     Citation Subset:  IM    
Affiliation:
From the *Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore; and †Department of Neurology, Singapore General Hospital, Singapore.
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