| Motor neuron trophic factors: Therapeutic use in ALS? | |
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MedLine Citation:
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PMID: 20971133 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The modest effects of neurotrophic factor (NTF) treatment on lifespan in both animal models and clinical studies of Amyotropic Lateral Sclerosis (ALS) may result from any one or combination of the four following explanations: 1.) NTFs block cell death in some physiological contexts but not in ALS; 2.) NTFs do not rescue motoneurons (MNs) from death in any physiological context; 3.) NTFs block cell death in ALS but to no avail; and 4.) NTFs are physiologically effective but limited by pharmacokinetic constraints. The object of this review is to critically evaluate the role of both NTFs and the intracellular cell death pathway itself in regulating the survival of spinal and cranial (lower) MNs during development, after injury and in response to disease. Because the role of molecules mediating MN survival has been most clearly resolved by the in vivo analysis of genetically engineered mice, this review will focus on studies of such mice expressing reporter, null or other mutant alleles of NTFs, NTF receptors, cell death or ALS-associated genes. |
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Authors:
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Thomas W Gould; Ronald W Oppenheim |
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Publication Detail:
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Type: Journal Article Date: 2010-10-21 |
Journal Detail:
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Title: Brain research reviews Volume: 67 ISSN: 1872-6321 ISO Abbreviation: Brain Res Rev Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101300366 Medline TA: Brain Res Rev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1-39 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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