Document Detail

Motor nerve conduction velocity in very preterm infants in relation to L-thyroxine supplementation.
MedLine Citation:
PMID:  9470002     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Transient hypothyroxinemia is common in preterm infants and has been associated with neurodevelopmental dysfunction and slow nerve conduction velocity. It is still unknown whether L-thyroxine supplementation is required. During an L-thyroxine supplementation trial, motor nerve conduction velocity was measured to answer the question whether L-thyroxine supplementation improves motor nerve conduction velocity. METHODS: Two hundred infants < 30 weeks' gestational age were enrolled in a randomized, double-blind, placebo-controlled L-thyroxine supplementation trial. L-Thyroxine (8 micrograms/kg birthweight per day) or a placebo was administered during the first 6 weeks of life. Motor nerve conduction velocity was measured in the ulnar and posterior tibial nerve shortly after birth, at 2 weeks, at 40 weeks, and at 66 weeks postmenstrual age. RESULTS: At 2 weeks, the ulnar motor nerve conduction velocity had improved in the L-thyroxine group compared with the placebo group, although the difference was not statistically significant (difference between means: 0.8 msec; 95% CI: -0.13 to 1.80; p = 0.06). Later on, no effect of L-thyroxine supplementation on motor nerve conduction velocity was found. CONCLUSION: This study shows that in infants < 30 weeks' gestational age L-thyroxine supplementation during the first 6 weeks of life does not clearly improve motor nerve conduction velocity.
B J Smit; J H Kok; L S de Vries; A G van Wassenaer; F W Dekker; B W Ongerboer de Visser
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  132     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-24     Completed Date:  1998-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  64-9     Citation Subset:  AIM; IM    
Academic Medical Center, University of Amsterdam, Emma Children's Hospital AMC Department of Neonatology, The Netherlands.
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MeSH Terms
Double-Blind Method
Follow-Up Studies
Infant, Newborn
Infant, Premature*
Linear Models
Motor Neurons / drug effects*
Neural Conduction / drug effects*
Thyroxine / administration & dosage*,  blood,  pharmacology
Tibial Nerve
Ulnar Nerve
Reg. No./Substance:

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