| Motor nerve conduction velocity in very preterm infants in relation to L-thyroxine supplementation. | |
| | |
MedLine Citation:
|
PMID: 9470002 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Transient hypothyroxinemia is common in preterm infants and has been associated with neurodevelopmental dysfunction and slow nerve conduction velocity. It is still unknown whether L-thyroxine supplementation is required. During an L-thyroxine supplementation trial, motor nerve conduction velocity was measured to answer the question whether L-thyroxine supplementation improves motor nerve conduction velocity. METHODS: Two hundred infants < 30 weeks' gestational age were enrolled in a randomized, double-blind, placebo-controlled L-thyroxine supplementation trial. L-Thyroxine (8 micrograms/kg birthweight per day) or a placebo was administered during the first 6 weeks of life. Motor nerve conduction velocity was measured in the ulnar and posterior tibial nerve shortly after birth, at 2 weeks, at 40 weeks, and at 66 weeks postmenstrual age. RESULTS: At 2 weeks, the ulnar motor nerve conduction velocity had improved in the L-thyroxine group compared with the placebo group, although the difference was not statistically significant (difference between means: 0.8 msec; 95% CI: -0.13 to 1.80; p = 0.06). Later on, no effect of L-thyroxine supplementation on motor nerve conduction velocity was found. CONCLUSION: This study shows that in infants < 30 weeks' gestational age L-thyroxine supplementation during the first 6 weeks of life does not clearly improve motor nerve conduction velocity. |
| | |
Authors:
|
B J Smit; J H Kok; L S de Vries; A G van Wassenaer; F W Dekker; B W Ongerboer de Visser |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of pediatrics Volume: 132 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1998 Jan |
Date Detail:
|
Created Date: 1998-02-24 Completed Date: 1998-02-24 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 64-9 Citation Subset: AIM; IM |
Affiliation:
|
Academic Medical Center, University of Amsterdam, Emma Children's Hospital AMC Department of Neonatology, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Double-Blind Method Female Follow-Up Studies Humans Infant Infant, Newborn Infant, Premature* Linear Models Male Motor Neurons / drug effects* Neural Conduction / drug effects* Thyroxine / administration & dosage*, blood, pharmacology Tibial Nerve Ulnar Nerve |
| Chemical | |
Reg. No./Substance:
|
7488-70-2/Thyroxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluation of criteria for chronic lung disease in surviving very low birth weight infants. Newborn ...
Next Document: Follow-up of newborns with low thyroxine and nonelevated thyroid-stimulating hormone-screening conce...