| Motor learning: nonspecific subcortical mechanisms in rats. | |
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MedLine Citation:
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PMID: 3606364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adult rats with bilateral lesions in the globus pallidus, substantia nigra, median raphe, midbrain central gray, or pontine reticular formation were tested for novel motor skill learning (sliding a barrel bolt to the right in order to open a door leading to a reward). Significantly impaired learning was found in animals with lesions to globus pallidus, substantia nigra, median raphe, or pontine reticular formation. These results combined with earlier findings suggest that the foregoing subcortical structures along with the regions of the ventrolateral and parafascicular nuclei of the thalamus constitute a nonspecific mechanism involved not only in motor learning but in discrimination and maze learning as well. This mechanism is contrasted with the more fashionable specific mechanisms which are involved in particular classes of learning; the sensorimotor cortex, for example, would be a component of the specific mechanism underlying motor learning. A subcortical nonspecific learning mechanism may also inhabit the human brain, as suggested by the clinical condition of "subcortical dementia." |
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Authors:
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R Thompson; P W Huestis; J Yu |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Archives of physical medicine and rehabilitation Volume: 68 ISSN: 0003-9993 ISO Abbreviation: Arch Phys Med Rehabil Publication Date: 1987 Jul |
Date Detail:
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Created Date: 1987-08-13 Completed Date: 1987-08-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985158R Medline TA: Arch Phys Med Rehabil Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 419-22 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / physiology* Brain Injuries / physiopathology Conditioning (Psychology) / physiology Learning / physiology* Male Motor Skills / physiology* Rats Rats, Inbred Strains |
| Comments/Corrections | |
Erratum In:
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Arch Phys Med Rehabil 1987 Dec;68(12):861 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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