Document Detail


Motor innervation of the gastrocnemius muscle of wobbler and dystrophic mice.
MedLine Citation:
PMID:  521835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Innervation of the gastrocnemius muscle of mice from the wobbler, dystrophic and C57/BL colonies has been studied. It was found that phenotypically normal mice from each of the colonies did not differ in their innervation properties, hence suggesting no heterozygote penetrance. However, the end-plate complexity increased with age of normal mice. Functional terminal innervation ratio for both the wobbler and dystrophic gastrocnemius muscle was raised above that of the normal and many dystrophic end-plates also appeared abnormal. A study of mice from the wobbler colony manifesting a late onset hind-limb muscle degeneration (Wr/HLD) has been included and the results suggest a relatively benign form of spinal muscular atrophy.
Authors:
S J Lewkowicz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  43     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  1979 Nov 
Date Detail:
Created Date:  1980-03-17     Completed Date:  1980-03-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  405-19     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Mice
Mice, Inbred C57BL
Mice, Neurologic Mutants
Motor Endplate / pathology
Muscles / innervation*,  metabolism,  pathology
Muscular Dystrophy, Animal / metabolism,  pathology*

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