Document Detail

Motor impairment in Wilson's disease. 3: The clinical impact of pyramidal tract involvement.
MedLine Citation:
PMID:  7976229     Owner:  NLM     Status:  MEDLINE    
Magnetic brain stimulation was performed on 24 patients with Wilson's disease (WD). Responses to the right and left first dorsal interosseus muscle (FDI) and to the right and left tibialis anterior muscle (TA) were analysed. In 45% of the patients prolonged central motor conduction times (CCTs) to the FDIs were found, whereas only 12% of the patients presented with prolonged CCTs to the TA muscles. No consistent significant correlations between copper metabolism and pyramidal tract function tested by magnetic brain stimulation were found. An improvement of CCTs and response amplitudes with copper elimination therapy was observed only at early phases of therapy. There was no correlation with duration of therapy or neurological symptoms. Thus magnetic brain stimulation turns out to be sensitive to detect subclinical pyramidal tract impairment in WD but seems to test a too specific aspect of motor impairment in WD to reflect the overall neurological status of the patients. Therefore, it has to be combined with other tests to be used for therapy control.
H Hefter; H Roick; H J von Giesen; G Arendt; P Weiss; W Stremmel; R Benecke
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  89     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-11-28     Completed Date:  1994-11-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  421-8     Citation Subset:  IM    
Department of Neurology, University of Düsseldorf, Germany.
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MeSH Terms
Brain / physiopathology*
Chelation Therapy
Copper / blood,  metabolism
Hepatolenticular Degeneration / drug therapy,  physiopathology*,  therapy*
Muscle, Skeletal / physiopathology*
Penicillamine / administration & dosage,  therapeutic use
Pyramidal Tracts / physiopathology*
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
52-67-5/Penicillamine; 7440-50-8/Copper

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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