| Motor evoked potentials in a mouse model of chronic multiple sclerosis. | |
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MedLine Citation:
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PMID: 16307439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We tested cortical motor evoked potentials (cMEPs) as a quantitative marker for in vivo monitoring of corticospinal tract damage in a murine multiple sclerosis model (experimental autoimmune encephalomyelitis, EAE). The cMEPs, previously standardized in naive C57BL/6 developing and adult mice, were studied longitudinally in adult EAE mice. Central conduction times (CCTs) increased significantly shortly before the earliest clinical signs developed (10 days postimmunization, dpi), with peak delay in acute EAE (20-40 dpi). In clinically stable disease (80 dpi), CCTs did not increase further, but cMEP amplitude declined progressively, with complete loss in >80% of mice at 120 dpi. Increase in CCT correlated with presence of inflammatory infiltrates and demyelination in acute EAE, whereas small or absent cMEPs were associated with continuing axonal damage in clinically-stabilized disease and beyond (>80 dpi). These results demonstrate that cMEPs are a useful method for monitoring corticospinal tract function in chronic-progressive EAE, and provide insight into the pathological substrate of the condition. |
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Authors:
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Stefano Amadio; Stefano Pluchino; Elena Brini; Paolo Morana; Roberta Guerriero; Filippo Martinelli Boneschi; Giancarlo Comi; Paola Zaratin; Valeria Muzio; Ubaldo del Carro |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Muscle & nerve Volume: 33 ISSN: 0148-639X ISO Abbreviation: Muscle Nerve Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-23 Completed Date: 2006-04-11 Revised Date: 2012-02-16 |
Medline Journal Info:
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Nlm Unique ID: 7803146 Medline TA: Muscle Nerve Country: United States |
Other Details:
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Languages: eng Pagination: 265-73 Citation Subset: IM |
Affiliation:
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Department of Neurology and Clinical Neurophysiology, San Raffaele Scientific Institute, Università Vita e Salute, Milan, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Central Nervous System / physiopathology Chronic Disease Demyelinating Autoimmune Diseases, CNS / physiopathology Demyelinating Diseases / physiopathology Disease Models, Animal Disease Progression Electric Stimulation Encephalomyelitis, Autoimmune, Experimental / physiopathology* Evoked Potentials, Motor* Female Mice Mice, Inbred C57BL Multiple Sclerosis / physiopathology* Nerve Degeneration Neural Conduction* Pyramidal Tracts / physiopathology Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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