| Motor effect of dopamine on human sigmoid colon. Evidence for specific receptors. | |
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MedLine Citation:
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PMID: 665614 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of dopamine on human sigmoid motility has been studied in 26 subjects. To record mechanical activity of the sigmoid colon, two small, air-filled balloons mounted on a probe introduced through a sigmoidoscope were used. The recordings were made at a distance of 25 and 15 cm from the anal edge. Dopamine was infused for 10 min after a 30-min control infusion of physiologic solution. Mean amplitude, mean duration, mean frequency, percentage of motor activity, and motility index of the pressure waves were determined. The motor response to dopamine was characterized by an increased baseline pressure with phasic waves superimposed. Dopamine produced a significant response at the dose of 5 microgram/kg/min. Alpha and beta antagonizing agents failed to oppose the effect of dopamine, while anticholinergic drugs enhanced its motor action. These studies suggest that dopamine may stimulate the motor function of human large bowel through specific receptors. |
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Authors:
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G A Lanfranchi; L Marzio; C Cortini; E M Osset |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of digestive diseases Volume: 23 ISSN: 0002-9211 ISO Abbreviation: Am J Dig Dis Publication Date: 1978 Mar |
Date Detail:
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Created Date: 1978-08-14 Completed Date: 1978-08-14 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0404011 Medline TA: Am J Dig Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 257-63 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Atropine
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pharmacology Blood Pressure / drug effects Colon / drug effects* Dopamine / pharmacology* Gastrointestinal Motility / drug effects* Heart Rate / drug effects Humans Propranolol / pharmacology Receptors, Dopamine* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Dopamine; 51-55-8/Atropine; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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