Document Detail

Motor dysfunction of the upper digestive tract in Pierre Robin sequence as assessed by sucking-swallowing electromyography and esophageal manometry.
MedLine Citation:
PMID:  12072876     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate motor dysfunction in infants with Pierre Robin sequence (PRS) who manifest upper airway obstruction and congenital dysphagia. STUDY DESIGN: Term infants (n = 28) with nonsyndromic PRS were studied between days 15 and 45. Sucking-swallowing electromyography was used to evaluate suction and coordination between the oral and pharyngeal phases of swallowing. Esophageal manometry was used to study the lower esophageal sphincter, esophageal body, and upper esophageal sphincter functions. Manometry results were compared with those of 16 infants with gastroesophageal reflux disease (GERD). RESULTS: Electromyography showed incoordination of sucking and swallowing in 24 of 28 patients. The disorder was mild in 6, moderate in 6, and severe in 12 patients. All patients showed manometry disturbances: incomplete or asynchronous lower sphincter relaxation (15), multipeaked esophageal body waves (17), very high amplitude waves (14), and asynchronous upper sphincter relaxation (19). The frequency of disturbances and mean resting pressures of both lower and upper sphincters were significantly higher than GERD patients. CONCLUSION: In Pierre Robin sequence, sucking-swallowing electromyography and esophageal manometry reveal dysfunction in the motor organization of the tongue, the pharynx, and the esophagus.
Jean-Jacques Baudon; Francis Renault; Jean-Michel Goutet; Roberto Flores-Guevara; Véronique Soupre; Francis Gold; Marie-Paule Vazquez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  140     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-19     Completed Date:  2002-07-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  719-23     Citation Subset:  AIM; IM    
Service de Néonatologie, Unité de Neurophysiologie Clinique, Hôpital d'Enfants Armand-Trousseau, Paris, France.
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MeSH Terms
Esophagus / physiopathology*
Gastroesophageal Reflux / physiopathology
Pharynx / physiopathology*
Pierre Robin Syndrome / physiopathology*
Tongue / physiopathology*

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