Document Detail

Motor development of very low birthweight infants with chronic lung disease - a comparative study.
MedLine Citation:
PMID:  16123812     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: To determine whether chronic lung disease (CLD) influences specific aspects of motor development in infancy. MATERIALS AND METHODS: Twenty-nine very low birthweight infants with CLD at 36 weeks' post-conceptional age and 31 infants without CLD were evaluated at 8 months' and 24 months' corrected age using the Neurosensory Motor Development Assessment. Perinatal and neonatal characteristics of the infants with CLD and control infants were compared using the chi-square test for categorical variables and Student's t-test for continuous variables. The relationship between CLD and adverse outcome was measured by the odds ratio (OR) and its 95% confidence interval (CI). RESULTS: The overall developmental scores of the CLD infants were significantly different compared with control infants at 8 months. By 2 years of age, both groups of infants showed marked improvement in motor performance. However, differences persisted in the area of postural balance and sensory motor skills. Taking periventricular haemorrhage and periventricular leukomalacia into consideration, CLD contributed significantly to the occurrence of motor dysfunction at 8 months of age [odds ratio (OR), 7.4; 95% confidence interval (CI), 2.1 to 26.5]. The impact of CLD on motor development remained substantial, though not statistically significant (OR, 3.7; 95% CI, 0.4 to 37.9) at 2 years of age. CONCLUSION: CLD has a definite effect on motor development. The pathologic influence of CLD on motor development remains speculative but results of this study emphasise the need for careful neurodevelopmental follow-up of infants with CLD, whether or not these infants suffer intraventricular haemorrhage or periventricular leukomalacia.
C L Yeo; C Chan
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the Academy of Medicine, Singapore     Volume:  34     ISSN:  0304-4602     ISO Abbreviation:  Ann. Acad. Med. Singap.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-26     Completed Date:  2005-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503289     Medline TA:  Ann Acad Med Singapore     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  411-6     Citation Subset:  IM    
Department of Neonatal and Developmental Medicine, Singapore General Hospital, Singapore.
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MeSH Terms
Bronchopulmonary Dysplasia / complications*,  diagnosis*
Case-Control Studies
Child Development / physiology
Child, Preschool
Chronic Disease
Confidence Intervals
Follow-Up Studies
Infant, Newborn
Infant, Very Low Birth Weight*
Motor Skills Disorders / epidemiology*,  etiology*,  physiopathology
Odds Ratio
Reference Values
Risk Assessment
Severity of Illness Index
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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