Document Detail

Motor deficits and schizophrenia: the evidence from neuroleptic-naïve patients and populations at risk.
MedLine Citation:
PMID:  10516797     Owner:  NLM     Status:  MEDLINE    
Patients with schizophrenia and high-risk populations have elevated rates of eye movement abnormalities. However, it is not known whether these abnormalities are specific to eye movements or whether they are also found in more traditional domains of motor control. Most studies examining the motor function of patients with schizophrenia have involved patients treated with medication; abnormalities in motor function could be a result of treatment rather than the disease itself. If motor abnormalities are related to schizophrenia, they should also be found in neuroleptic-naïve patients and possibly in high-risk populations in whom eye movement abnormalities are also observed. We reviewed relevant empirical papers published in the last 35 years. Results suggest that approximately one-fifth of neuroleptic-naïve patients with schizophrenia have increased rates of parkinsonism and neurological soft signs. In high-risk populations, replicated findings include delayed motor development in preschizophrenia subjects, and poor motor skills in the offspring of patients with schizophrenia. In first-degree relatives, increased rates of neurological soft signs were reported. These findings suggest that motor abnormalities are not limited to eye movements and may constitute markers of vulnerability. The literature has several weaknesses that should be addressed in future studies.
A L Wolff; G A O'Driscoll
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Journal of psychiatry & neuroscience : JPN     Volume:  24     ISSN:  1180-4882     ISO Abbreviation:  J Psychiatry Neurosci     Publication Date:  1999 Sep 
Date Detail:
Created Date:  2000-02-29     Completed Date:  2000-02-29     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9107859     Medline TA:  J Psychiatry Neurosci     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  304-14     Citation Subset:  IM    
Department of Psychology, McGill University, Montreal, Que.
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MeSH Terms
Antipsychotic Agents / adverse effects*
Middle Aged
Parkinsonian Disorders / etiology*
Risk Factors
Schizophrenia / complications*,  drug therapy*
Reg. No./Substance:
0/Antipsychotic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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