Document Detail


Motor current waveforms as an index for evaluation of native cardiac function during left ventricular support with a centrifugal blood pump.
MedLine Citation:
PMID:  11722346     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Control of ventricular assist devices (VADs) for native heart preservation should be attempted, and it could be one strategy for dealing with the shortage of donors in the future. In the application of a nonpulsatile blood pump for ventricular assistance from its apex to the aorta, the bypass flow and hence motor current of the pumps change in response to the ventricular pressure change. Utilizing these intrinsic characteristics of the continuous flow pumps, this study investigated whether or not motor current could be used as an index for continuous monitoring of native cardiac function. In Study 1, a centrifugal blood pump (CFP) VAD was installed between the apex and descending aorta of a mock circulatory loop. In this model, a baseline with a preload of 10 mm Hg, afterload of 40 mm Hg, and left ventricular (LV) systolic pressure of 40 mm Hg was used. The pump rpm were fixed at 1,300, 1,500, and 1,700, and LV systolic pressure was increased up to 140 mm Hg by a step of 20 mm Hg while observing the changes in LV pressure, motor current, pump flow, and aortic pressure. In Study 2, in vivo experiments were performed using 5 sheep. A left heart bypass model was created using a centrifugal pump from the ventricular apex to the descending aorta. The LV pressure was varied through administration of dopamine while observing the changes in LV pressure, pump flow, motor current, and aortic pressure at 1,500 and 1,700 rpm. An excellent correlation was observed both in vitro and in vivo studies in the relationship between motor current and LV pressure. In Study 1, the correlation coefficients were 0.77, 0.92, and 0.99 for 1,300, 1,500, and 1,700 rpm, respectively. In Study 2, they were 0.90 (Animal 1), 0.82 (Animal 2), 0.89 (Animal 3), 0.93 (Animal 4), and 0.70 (Animal 5) respectively for 1,500 rpm, and 0.94 (Animal 2), 0.85 (Animal 3), 0.94 (Animal 4), and 0.89 (Animal 5) respectively, for 1,700 rpm. The relationship between motor current and pump flow and LV pressure showed an unstable correlation in an in vivo study. These results suggest that motor current amplitude monitoring could be useful as an index for the control of VADs for native heart preservation.
Authors:
D Kikugawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Artificial organs     Volume:  25     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-11-27     Completed Date:  2002-01-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  703-8     Citation Subset:  IM    
Affiliation:
Department of Thoracic and Cardiovascular Surgery, Kawasaki Medical School, 577 Matsushima, Kurashiki, Japan. kikugawa@med.kawasaki-m.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Centrifugation
Heart-Assist Devices*
Hemorheology / instrumentation
Models, Cardiovascular
Sheep
Signal Processing, Computer-Assisted
Ventricular Function, Left / physiology
Ventricular Pressure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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