| Motor cortical inhibition and the dopaminergic system. Pharmacological changes in the silent period after transcranial brain stimulation in normal subjects, patients with Parkinson's disease and drug-induced parkinsonism. | |
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MedLine Citation:
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PMID: 8186958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The silent period after contralateral and ipsilateral transcranial magnetic brain stimulation was studied in patients with Parkinson's disease before and after dopaminergic and anticholinergic therapy; in normal subjects before and after L-dopa administration and in patients with drug-induced parkinsonism. In patients and normal subjects the silent period was also studied after peripheral nerve stimulation. The silent period after transcranial cortical stimulation was shorter in Parkinson's disease patients than in normal subjects. In patients with Parkinson's disease L-dopa prolonged the silent period after transcranial brain stimulation and after ipsilateral cortical stimulation. Biperiden prolonged the silent period after transcranial brain stimulation. In normal subjects, L-dopa produced similar but smaller changes. In the patients with drug-induced parkinsonism the silent period after transcranial magnetic stimulation was shorter than normal subjects. The peripheral silent period was similar in normal subjects and in patients and did not change after drug administration. In conclusion cortical silent period is abnormal in patients with Parkinson's disease and drug-induced parkinsonism. Dopaminergic drugs modulate the duration of the cortical silent periods in patients and in normal subjects, through mechanisms acting mainly at basal ganglia and possibly also directly at cortical level. |
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Authors:
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A Priori; A Berardelli; M Inghilleri; N Accornero; M Manfredi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brain : a journal of neurology Volume: 117 ( Pt 2) ISSN: 0006-8950 ISO Abbreviation: Brain Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-06-22 Completed Date: 1994-06-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372537 Medline TA: Brain Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 317-23 Citation Subset: AIM; IM |
Affiliation:
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Dipartimento Scienze Neurologiche, Università degli Studi di Roma, La Sapienza, Italia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biperiden / pharmacology Brain / metabolism, physiopathology* Electric Stimulation Evoked Potentials / drug effects Female Humans Levodopa / administration & dosage* Magnetics Male Middle Aged Motor Cortex / physiopathology* Muscles / drug effects, physiopathology* Parkinson Disease / metabolism, physiopathology* Parkinson Disease, Secondary / metabolism, physiopathology* Peripheral Nerves / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Levodopa; 514-65-8/Biperiden |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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