Document Detail

Motor and cognitive outcome in patients with Parkinson's disease 8 years after subthalamic implants.
MedLine Citation:
PMID:  20802207     Owner:  NLM     Status:  MEDLINE    
Deep brain stimulation of the subthalamic nucleus represents the most important innovation for treatment of advanced Parkinson's disease. Prospective studies have shown that although the beneficial effects of this procedure are maintained at 5 years, axial motor features and cognitive decline may occur in the long term after the implants. In order to address some unsolved questions raised by previous studies, we evaluated a series of 20 consecutive patients who received continuous stimulation for 8 years. The overall motor improvement reported at 5 years (55.5% at Unified Parkinson's Disease Rating Scale-motor part, P < 0.001 compared with baseline) was only partly retained 3 years later (39%, P < 0.001, compared with baseline; -16.5%, P < 0.01, compared with 5 years), with differential effects on motor features: speech did not improve and postural stability worsened (P < 0.05). The preoperative levodopa equivalent daily dose was reduced by 58.2% at 5 years and by 60.3% at 8 years. In spite of subtle worsening of motor features, a dramatic impairment in functional state (-56.6% at Unified Parkinson's Disease Rating Scale-Activities of Daily Living, P < 0.01) emerged after the fifth year of stimulation. The present study did not reveal a predictive value of preoperative levodopa response, whereas few single features at baseline (such as gait and postural stability motor scores and the preoperative levodopa equivalent daily dose) could predict long-term motor outcome. A decline in verbal fluency (slightly more pronounced than after 5 years) was detected after 8 years. A significant but slight decline in tasks of abstract reasoning, episodic memory and executive function was also found. One patient had developed dementia at 5 years with further progression at 8 years. Executive dysfunction correlated significantly with postural stability, suggesting interplay between axial motor deterioration and cognition. Eight years after surgery, no significant change was observed on scales assessing depression or anxiety when compared with baseline. At 8 years, there was no significant increase of side-effects when compared with 5-year follow-up. In conclusion, deep brain stimulation of the subthalamic nucleus is a safe procedure with regard to cognitive and behavioural morbidity over long-term follow-up. However, the global benefit partly decreases later in the course of the disease, due to progression of Parkinson's disease and the appearance of medication- and stimulation-resistant symptoms.
Alfonso Fasano; Luigi M Romito; Antonio Daniele; Carla Piano; Massimiliano Zinno; Anna Rita Bentivoglio; Alberto Albanese
Related Documents :
6142657 - Propranolol in the treatment of neuroleptic-induced akathisia.
21491237 - Isolation from predators: a key factor in the failed release of farmed red-legged partr...
21341127 - Comparison of classical surgery and sutureless repair with duraseal or fibrin glue for ...
21317777 - Evaluation of the analgesic efficacy of local dexmedetomidine application.
12188487 - Biaxial total wrist replacement in patients with rheumatoid arthritis. clinical review,...
21878847 - Topical aqueous suppression does not significantly affect duration of intraocular gas t...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain : a journal of neurology     Volume:  133     ISSN:  1460-2156     ISO Abbreviation:  Brain     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-30     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372537     Medline TA:  Brain     Country:  England    
Other Details:
Languages:  eng     Pagination:  2664-76     Citation Subset:  AIM; IM    
Istituto di Neurologia, Università Cattolica del Sacro Cuore, Rome, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cognition Disorders / etiology,  therapy*
Deep Brain Stimulation / methods*
Gait Disorders, Neurologic / etiology,  therapy
Longitudinal Studies
Middle Aged
Motor Activity / physiology*
Neurologic Examination
Neuropsychological Tests
Parkinson Disease / complications,  therapy*
Retrospective Studies
Statistics, Nonparametric
Subthalamic Nucleus / physiology*
Syncope / etiology,  therapy
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinson's disease.
Next Document:  Preferential use of protein domain pairs as interaction mediators: order and transitivity.