| Motor activity affects dopaminergic and noradrenergic systems of the dorsal horn of the rat lumbar spinal cord. | |
| | |
MedLine Citation:
|
PMID: 21538552 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Dopamine (DA) and noradrenaline (NA) modulate responses to nociceptive stimuli, within the dorsal horn of the spinal cord. Both neurotransmitters may play a role in supra-spinal regulation or response to proprioceptive afferences to the dorsal horn. However, direct evidence of changes in neurotransmitter release within the dorsal horn due to non-noxious stimuli is lacking. The present study was designed to determine, whether non-nociceptive exercise produces changes in release of DA and NA within the dorsal horn and, whether these changes are associated with long-lasting inhibition after the exercise stops. Microdialysis probes, implanted in layers 2-5 of Rexed, in combination with HPLC-EC were used to measure concentrations of DA and NA metabolite 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) in lumbar spinal cords of rats. Microdialysate was sampled before, during and after a treadmill exercise of one hour. Results indicate that DA and NA releases are inhibited during non-nociceptive motor activity. At rest, DA concentration was 204 ± 10.5 pg/10μL and was significantly decreased during exercise of - 11.4% (P ≤ 0.05). Greater decrease occurred after 30 min of exercise and was of - 31.4% (P ≤ 0.05). Similarly, MHPG was significantly decreased of - 18% during exercise (P ≤ 0.05). When exercise stopped, both systems showed long-lasting inhibition. Exercise post-release lasted 30 min for DA and 90 min for MHPG. MHPG greatest decrease of - 47.8% occured 30 min after stopping the exercise (P ≤ 0.001). Thus, DA and NA systems seem to respond to exercise-induced proprioceptive afferent stimuli to the dorsal horn. Synapse, 2011. © 2011 Wiley-Liss, Inc. |
| | |
Authors:
|
Christine G Gerin; Kristin Smith; Seritta Hill; Angela Hill; Ikenna C Madueke |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-29 |
Journal Detail:
|
Title: Synapse (New York, N.Y.) Volume: - ISSN: 1098-2396 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-5-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8806914 Medline TA: Synapse Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
|
Department of Anatomy and Cell Biology, UIC, Chicago, Illinois 60612. cgerin@uic.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Enhancement of histone acetylation in midbrain of mice with ethanol physical dependence and its with...
Next Document: Effects of potential dietary inhibitors of endogenous DNA damage on mutagenesis and lipid peroxidati...