Document Detail


Motor activity affects dopaminergic and noradrenergic systems of the dorsal horn of the rat lumbar spinal cord.
MedLine Citation:
PMID:  21538552     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Dopamine (DA) and noradrenaline (NA) modulate responses to nociceptive stimuli, within the dorsal horn of the spinal cord. Both neurotransmitters may play a role in supra-spinal regulation or response to proprioceptive afferences to the dorsal horn. However, direct evidence of changes in neurotransmitter release within the dorsal horn due to non-noxious stimuli is lacking. The present study was designed to determine, whether non-nociceptive exercise produces changes in release of DA and NA within the dorsal horn and, whether these changes are associated with long-lasting inhibition after the exercise stops. Microdialysis probes, implanted in layers 2-5 of Rexed, in combination with HPLC-EC were used to measure concentrations of DA and NA metabolite 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) in lumbar spinal cords of rats. Microdialysate was sampled before, during and after a treadmill exercise of one hour. Results indicate that DA and NA releases are inhibited during non-nociceptive motor activity. At rest, DA concentration was 204 ± 10.5 pg/10μL and was significantly decreased during exercise of - 11.4% (P ≤ 0.05). Greater decrease occurred after 30 min of exercise and was of - 31.4% (P ≤ 0.05). Similarly, MHPG was significantly decreased of - 18% during exercise (P ≤ 0.05). When exercise stopped, both systems showed long-lasting inhibition. Exercise post-release lasted 30 min for DA and 90 min for MHPG. MHPG greatest decrease of - 47.8% occured 30 min after stopping the exercise (P ≤ 0.001). Thus, DA and NA systems seem to respond to exercise-induced proprioceptive afferent stimuli to the dorsal horn. Synapse, 2011. © 2011 Wiley-Liss, Inc.
Authors:
Christine G Gerin; Kristin Smith; Seritta Hill; Angela Hill; Ikenna C Madueke
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-29
Journal Detail:
Title:  Synapse (New York, N.Y.)     Volume:  -     ISSN:  1098-2396     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-5-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806914     Medline TA:  Synapse     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Affiliation:
Department of Anatomy and Cell Biology, UIC, Chicago, Illinois 60612. cgerin@uic.edu.
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