Document Detail


Motor and premotor cortices in subcortical stroke: proton magnetic resonance spectroscopy measures and arm motor impairment.
MedLine Citation:
PMID:  23300210     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although functional imaging and neurophysiological approaches reveal alterations in motor and premotor areas after stroke, insights into neurobiological events underlying these alterations are limited in human studies.
OBJECTIVE: We tested whether cerebral metabolites related to neuronal and glial compartments are altered in the hand representation in bilateral motor and premotor areas and correlated with distal and proximal arm motor impairment in hemiparetic persons.
METHODS: In 20 participants at >6 months postonset of a subcortical ischemic stroke and 16 age- and sex-matched healthy controls, the concentrations of N-acetylaspartate and myo-inositol were quantified by proton magnetic resonance spectroscopy. Regions of interest identified by functional magnetic resonance imaging included primary (M1), dorsal premotor (PMd), and supplementary (SMA) motor areas. Relationships between metabolite concentrations and distal (hand) and proximal (shoulder/elbow) motor impairment using Fugl-Meyer Upper Extremity (FMUE) subscores were explored.
RESULTS: N-Acetylaspartate was lower in M1 (P = .04) and SMA (P = .004) and myo-inositol was higher in M1 (P = .003) and PMd (P = .03) in the injured (ipsilesional) hemisphere after stroke compared with the left hemisphere in controls. N-Acetylaspartate in ipsilesional M1 was positively correlated with hand FMUE subscores (P = .04). Significant positive correlations were also found between N-acetylaspartate in ipsilesional M1, PMd, and SMA and in contralesional M1 and shoulder/elbow FMUE subscores (P = .02, .01, .02, and .02, respectively).
CONCLUSIONS: Our preliminary results demonstrated that proton magnetic resonance spectroscopy is a sensitive method to quantify relevant neuronal changes in spared motor cortex after stroke and consequently increase our knowledge of the factors leading from these changes to arm motor impairment.
Authors:
Sorin C Craciunas; William M Brooks; Randolph J Nudo; Elena A Popescu; In-Young Choi; Phil Lee; Hung-Wen Yeh; Cary R Savage; Carmen M Cirstea
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-01-08
Journal Detail:
Title:  Neurorehabilitation and neural repair     Volume:  27     ISSN:  1552-6844     ISO Abbreviation:  Neurorehabil Neural Repair     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-03     Completed Date:  2013-12-03     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  100892086     Medline TA:  Neurorehabil Neural Repair     Country:  United States    
Other Details:
Languages:  eng     Pagination:  411-20     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aspartic Acid / analogs & derivatives*,  metabolism
Female
Functional Laterality
Humans
Imaging, Three-Dimensional
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Male
Middle Aged
Motor Cortex / blood supply,  metabolism,  radionuclide imaging*
Movement Disorders / etiology*
Protons / diagnostic use
Statistics as Topic
Stroke / complications,  pathology*,  radionuclide imaging
Grant Support
ID/Acronym/Agency:
P30 AG035982/AG/NIA NIH HHS; P30 AG035982/AG/NIA NIH HHS; P30 HD002528/HD/NICHD NIH HHS; R01 AG033673/AG/NIA NIH HHS; R01 DK080090/DK/NIDDK NIH HHS; R01 DK085605/DK/NIDDK NIH HHS; R37 NS030853/NS/NINDS NIH HHS; R37 NS030853/NS/NINDS NIH HHS; S10 RR29577/RR/NCRR NIH HHS; UL1 RR033179/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Protons; 30KYC7MIAI/Aspartic Acid; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  How to Discriminate between Computer-Aided and Computer-Hindered Decisions: A Case Study in Mammogra...
Next Document:  Priming Pharyngeal Motor Cortex by Repeated Paired Associative Stimulation: Implications for Dysphag...