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Motor neuron disease and serum monoclonal proteins: poor response to treatment of the paraproteinemia.
MedLine Citation:
PMID:  19078608     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
An association between motor neuron disease (MND) and paraproteinemia has been previously reported. In a retrospective study, we found that 13 of 117 (11%) patients with MND who had serum protein electrophoresis studies were found to have a serum M-protem. Eleven of 13 patients had probable or definite amyotrophic lateral sclerosis (ALS), Of the 11 patients with ALS, six were treated with immunotherapy or chemotherapy. Subjective or objective neurologic improvement was not identified in any. Our data support an association between MND and paraproteinemia, but response to treatment of the paraproteinemia was disappointing. Searching for an M-protein in probable or definite ALS may not be therapeutically relevant.
Authors:
M T Burns; V C Juel; C E Hess; L H Phillips
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical neuromuscular disease     Volume:  2     ISSN:  1537-1611     ISO Abbreviation:  J Clin Neuromuscul Dis     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2013-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100887391     Medline TA:  J Clin Neuromuscul Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  70-2     Citation Subset:  -    
Affiliation:
Neurology and Internal Medicine, University of Virginia School of Medicine, Charlottesville, Virginia.
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