Document Detail


Motoneuron firing patterns underlying fast oscillations in phrenic nerve discharge in the rat.
MedLine Citation:
PMID:  22815408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fast oscillations are ubiquitous throughout the mammalian central nervous system and are especially prominent in respiratory motor outputs, including the phrenic nerves (PhNs). Some investigators have argued for an epiphenomenological basis for PhN high-frequency oscillations because phrenic motoneurons (PhMNs) firing at these same frequencies have never been recorded, although their existence has never been tested systematically. Experiments were performed on 18 paralyzed, unanesthetized, decerebrate adult rats in which whole PhN and individual PhMN activity were recorded. A novel method for evaluating unit-nerve time-frequency coherence was applied to PhMN and PhN recordings. PhMNs were classified according to their maximal firing rate as high, medium, and low frequency, corresponding to the analogous bands in PhN spectra. For the first time, we report the existence of PhMNs firing at rates corresponding to high-frequency oscillations during eupneic motor output. The majority of PhMNs fired only during inspiration, but a small subpopulation possessed tonic activity throughout all phases of respiration. Significant time-varying PhMN-PhN coherence was observed for all PhMN classes. High-frequency, early-recruited units had significantly more consistent onset times than low-frequency, early/middle-recruited and medium-frequency, middle/late-recruited PhMNs. High- and medium-frequency PhMNs had significantly more consistent offset times than low-frequency units. This suggests that startup and termination of PhMNs with higher firing rates are more precisely controlled, which may contribute to the greater PhMN-PhN coherence at the beginning and end of inspiration. Our findings provide evidence that near-synchronous discharge of PhMNs firing at high rates may underlie fast oscillations in PhN discharge.
Authors:
Vitaliy Marchenko; Michael G Z Ghali; Robert F Rogers
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-18
Journal Detail:
Title:  Journal of neurophysiology     Volume:  108     ISSN:  1522-1598     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-16     Completed Date:  2013-03-27     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2134-43     Citation Subset:  IM    
Affiliation:
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Evoked Potentials, Motor*
Male
Motor Neurons / physiology*
Phrenic Nerve / physiology*
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
HL68143/HL/NHLBI NIH HHS; R01 NS069220/NS/NINDS NIH HHS
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