Document Detail

Motivational effects of methamphetamine as measured by the runway method using priming stimulation of intracranial self-stimulation behavior.
MedLine Citation:
PMID:  18379037     Owner:  NLM     Status:  MEDLINE    
Priming stimulation is known to promote the motivational effects of intracranial self-stimulation (ICSS) behavior. The runway method using priming stimulation can experimentally distinguish the reward and motivational effects of ICSS behavior. In this study, we examined the motivational effect of a drug as determined by the runway method using priming stimulation of ICSS behavior. Electrodes were implanted chronically into the medial forebrain bundle (MFB) of the rats. A lever for stimulation of the MFB was set on the opposite side of the start box in the apparatus. The rats were trained to obtain a reward stimulation (50-200 muA, 0.2 ms, 60 Hz) of the MFB by pressing the goal lever, and then priming stimulation of the MFB was applied. After priming stimulation, rats were placed in the start box of the runway apparatus and the time taken by the rat to press the lever was recorded. Priming stimulation frequency was significantly correlated with running speed (r=0.897, p<0.05). Methamphetamine (1, 3 mg/kg) induced an increase in running speed (F(3, 20)=16.257, p<0.01), and was further increased with increase in priming stimulation frequency. In addition, methamphetamine significantly enhanced the motivational effect. These results suggest that the runway method using priming stimulation of ICSS behavior may be an effective way to evaluate the enhancing effect of a drug on motivation.
Hidenori Sagara; Yoshihisa Kitamura; Toshiaki Sendo; Hiroaki Araki; Yutaka Gomita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  31     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-01     Completed Date:  2008-05-12     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  541-5     Citation Subset:  IM    
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MeSH Terms
Central Nervous System Stimulants / pharmacology*
Conditioning, Operant / drug effects*
Data Interpretation, Statistical
Electrodes, Implanted
Medial Forebrain Bundle / physiology
Methamphetamine / pharmacology*
Rats, Wistar
Reinforcement (Psychology)
Self Administration
Self Stimulation / drug effects*
Reg. No./Substance:
0/Central Nervous System Stimulants; 44RAL3456C/Methamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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