Document Detail


Motivation for palatable food despite consequences in an animal model of binge eating.
MedLine Citation:
PMID:  20186718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Binge eating involves an abnormal motivation for highly palatable food in that these foods are repeatedly consumed despite their binge-triggering effects and life-affecting consequences associated with binge eating. We determined if rats identified as binge-eating prone (BEP) similarly display abnormal motivation for palatable food.
METHOD: Food-sated BEP and binge-eating resistant (BER) rats were given voluntary access to palatable food paired with increasing intensity of footshock. Later, they were exposed to a period of cyclic caloric restriction-refeeding.
RESULTS: BEPs consumed significantly more and tolerated higher levels of footshock for palatable food than BERs. Cyclic restriction-refeeding increased BERs' tolerance of shock for palatable food.
DISCUSSION: Previously observed parallels of the rat BEP model to human binge eating can now be extended to include an abnormal motivation for palatable food. This model should prove useful in identifying specific genes that interact with the nutritional environment to mediate binge eating and may point to novel physiological targets to treat compulsive overeating.
Authors:
Kimberly D Oswald; Donna L Murdaugh; Vinetra L King; Mary M Boggiano
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The International journal of eating disorders     Volume:  44     ISSN:  1098-108X     ISO Abbreviation:  Int J Eat Disord     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-14     Completed Date:  2011-08-05     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8111226     Medline TA:  Int J Eat Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-11     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Wiley Periodicals, Inc.
Affiliation:
Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama 35294-1170, USA. koswald@uab.edu
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Behavior, Animal / physiology
Binge-Eating Disorder / psychology*
Choice Behavior / physiology
Diet
Disease Models, Animal
Eating / psychology
Electroshock
Feeding Behavior / physiology,  psychology*
Female
Motivation / physiology*
Rats
Rats, Sprague-Dawley
Satiety Response / physiology
Grant Support
ID/Acronym/Agency:
DK066007/DK/NIDDK NIH HHS; R03 DK066007-03/DK/NIDDK NIH HHS
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