| Motivation for palatable food despite consequences in an animal model of binge eating. | |
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MedLine Citation:
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PMID: 20186718 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Binge eating involves an abnormal motivation for highly palatable food in that these foods are repeatedly consumed despite their binge-triggering effects and life-affecting consequences associated with binge eating. We determined if rats identified as binge-eating prone (BEP) similarly display abnormal motivation for palatable food. METHOD: Food-sated BEP and binge-eating resistant (BER) rats were given voluntary access to palatable food paired with increasing intensity of footshock. Later, they were exposed to a period of cyclic caloric restriction-refeeding. RESULTS: BEPs consumed significantly more and tolerated higher levels of footshock for palatable food than BERs. Cyclic restriction-refeeding increased BERs' tolerance of shock for palatable food. DISCUSSION: Previously observed parallels of the rat BEP model to human binge eating can now be extended to include an abnormal motivation for palatable food. This model should prove useful in identifying specific genes that interact with the nutritional environment to mediate binge eating and may point to novel physiological targets to treat compulsive overeating. |
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Authors:
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Kimberly D Oswald; Donna L Murdaugh; Vinetra L King; Mary M Boggiano |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The International journal of eating disorders Volume: 44 ISSN: 1098-108X ISO Abbreviation: Int J Eat Disord Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-14 Completed Date: 2011-08-05 Revised Date: 2012-09-20 |
Medline Journal Info:
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Nlm Unique ID: 8111226 Medline TA: Int J Eat Disord Country: United States |
Other Details:
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Languages: eng Pagination: 203-11 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Wiley Periodicals, Inc. |
Affiliation:
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Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama 35294-1170, USA. koswald@uab.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Behavior, Animal / physiology Binge-Eating Disorder / psychology* Choice Behavior / physiology Diet Disease Models, Animal Eating / psychology Electroshock Feeding Behavior / physiology, psychology* Female Motivation / physiology* Rats Rats, Sprague-Dawley Satiety Response / physiology |
| Grant Support | |
ID/Acronym/Agency:
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DK066007/DK/NIDDK NIH HHS; R03 DK066007-03/DK/NIDDK NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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