| Motion sickness: a cholinomimetic agent hypothesis. | |
| | |
MedLine Citation:
|
PMID: 21846953 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Motion sickness has been defined as a set of physiological signs and symptoms produced as a result of prolonged sensory conflict in central nervous system vestibular centers. It has long been noted that the particular pattern of motion sickness signs and symptoms does not fit the conventional "fight or flight vs. rest and digest" autonomic synergy. We argue that most of the progression of symptoms is consistent with a new etiologic hypothesis: that an as-yet-unidentified ganglionic cholinomimetic agent is slowly released in proportion to sensory conflict. The agent accumulates systemically and stimulates the peripheral sympathetic and parasympathetic ganglia, the adrenal medulla, and potentiates the response of central cholinergic emetic pathways to the same conflict stimulus. The predominant effects of ganglionic stimulation on each autonomic organ, determined by resting tone, are selectively enhanced or inhibited by adrenal catecholamine release, producing the atypical pattern of autonomic changes seen in motion sickness. The adrenergic response may eventually also counter the central emetic drive. The hypothesis could be experimentally pursued via human and animal experiments employing a nicotinic antagonist that has both central and peripheral ganglionic actions such as mecamylamine. |
| | |
Authors:
|
Scott E Sheehan; Charles M Oman; Kevin R Duda |
Related Documents
:
|
18394523 - Temporal prediction of touch instant during observation of human and robot grasping. 13836073 - Action spectra for two effects of light on luminescence in gonyaulax polyedra. 10916183 - Visual phenotype in patients with arg41gln and ala196+1bp mutations in the crx gene. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Journal of vestibular research : equilibrium & orientation Volume: 21 ISSN: 1878-6464 ISO Abbreviation: J Vestib Res Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-08-17 Completed Date: 2011-12-13 Revised Date: 2012-03-28 |
Medline Journal Info:
|
Nlm Unique ID: 9104163 Medline TA: J Vestib Res Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 209-17 Citation Subset: IM; S |
Affiliation:
|
Brigham and Women's Hospital, Boston, MA, USA. sesheehan@partners.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Catecholamines / secretion Cholinergic Agents / pharmacology* Ganglia, Autonomic / drug effects Humans Models, Neurological Motion Sickness / physiopathology* Receptors, Nicotinic / physiology |
| Chemical | |
Reg. No./Substance:
|
0/Catecholamines; 0/Cholinergic Agents; 0/Receptors, Nicotinic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Differences between perception and eye movements during complex motions.
Next Document: Optokinetic response in patients with vestibular areflexia.