Document Detail

Motion correction in exercise first-pass radionuclide ventriculography without an external point source.
MedLine Citation:
PMID:  7472579     Owner:  NLM     Status:  MEDLINE    
Exercise first-pass radionuclide ventriculography provides valuable diagnostic and prognostic information in patients with coronary artery disease. In this procedure, motion correction of the images is commonly performed using a second external point source attached to the chest wall during exercise (dual-isotope method). Recently, a motion correction algorithm without an external point source (single-isotope method) was developed and the results compared with those of the dual-isotope method. METHODS: To examine the accuracy of the motion correction method, a phantom study was performed using a moving cardiac phantom with a motion speed of up to 169 cycle/min and motion amplitude up to 6 cm. Count fluctuation in the phantom region by motion was calculated as a coefficient of variation (CV). In the clinical study, time-activity curves of the left ventricular phase were created for quantitative assessment of variation as CV values of the ejection fraction in the central five cardiac cycles after correction by the two methods during exercise radionuclide ventriculography in 17 patients. RESULTS: In the moving phantom, both the single- and dual-isotope methods reduced the CV values less than 10%. In the clinical study, the single-isotope method provided less CV value of ejection fraction (9.8% +/- 5.6%) than the dual-isotope method (24.8% +/- 10.5%) (p < 0.01), indicating less individual variation of ejection fraction values. CONCLUSION: These data indicate that object motion can be accurately corrected in the moving phantom by both single- and dual-isotope methods. In clinical studies, the single-isotope method is more accurate.
S Yano; N Tamaki; T Fujita; S Shirakawa; N Takahashi; T Kudoh; N Hattori; Y Yonekura; J Konishi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  36     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1995-12-12     Completed Date:  1995-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1941-4     Citation Subset:  IM    
Department of Nuclear Medicine, Kyoto University Hospital, Japan.
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MeSH Terms
Coronary Disease / radionuclide imaging*
Exercise Test
Feasibility Studies
Iodine Radioisotopes / diagnostic use
Organophosphorus Compounds / diagnostic use
Organotechnetium Compounds / diagnostic use
Phantoms, Imaging
Stroke Volume / physiology
Ventriculography, First-Pass / methods*
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane

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