| Motion corrected cadence CPS ultrasound for quantifying response to vasoactive drugs in a rat kidney model. | |
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MedLine Citation:
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PMID: 19589583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To establish the ability of contrast-enhanced motion corrected cadence pulse sequencing (CPS) to detect changes in renal blood flow induced by vasoactive substances in rats. METHODS: Ultrasound contrast media was administered as a constant rate infusion into a phantom at a known rate and CPS data acquired. Rats were anesthetized and predrug CPS estimates of replenishment rate were made for the right kidney. Real-time motion correction was applied, and parametric images were generated from the CPS data. Group 1 rats (n = 7) were administered a vasodilator and group 2 rats (n = 3) were administered a vasoconstrictor. The CPS imaging of the kidney was repeated after ample time for drug effects to occur. RESULTS: Contrast CPS accurately estimated flow velocity in the phantom model. In addition, CPS defined statistically significant differences between pre- and postdrug blood flow in the renal medulla (vasodilator, P < .01; vasoconstrictor, P < .0001) and cortex (vasoconstrictor, P < .0001). CONCLUSIONS: We conclude that motion-corrected CPS ultrasound provides real-time quantification of renal blood flow alterations and may prove useful for the assessment of blood flow in transplanted kidneys. |
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Authors:
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Rachel E Pollard; Paul A Dayton; Katherine D Watson; Xiaowen Hu; Ismayil M Guracar; Katherine W Ferrara |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2009-07-09 |
Journal Detail:
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Title: Urology Volume: 74 ISSN: 1527-9995 ISO Abbreviation: Urology Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-31 Completed Date: 2009-09-16 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0366151 Medline TA: Urology Country: United States |
Other Details:
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Languages: eng Pagination: 675-81 Citation Subset: IM |
Affiliation:
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Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, California 95616, USA. repollard@ucdavis.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contrast Media / administration & dosage* Kidney / blood supply*, ultrasonography* Male Models, Animal Rats Rats, Sprague-Dawley Renal Circulation / drug effects* Ultrasonography / methods Vasoconstrictor Agents / pharmacology* Vasodilator Agents / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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CA76062/CA/NCI NIH HHS; R01 CA076062-03/CA/NCI NIH HHS; R01 CA076062-04/CA/NCI NIH HHS; R01 CA076062-05/CA/NCI NIH HHS; R01 CA076062-06/CA/NCI NIH HHS; R01 CA076062-07/CA/NCI NIH HHS; R01 CA076062-08/CA/NCI NIH HHS; R01 CA076062-09/CA/NCI NIH HHS; R01 CA076062-10/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Vasoconstrictor Agents; 0/Vasodilator Agents |
| Comments/Corrections | |
Comment In:
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Urology. 2009 Sep;74(3):681-2; author reply 682
[PMID:
19716926
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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