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Motion Analysis of Right Ventricular Dysfunction Under Mild or Moderate Pressure Overload Caused by Acute Pulmonary Embolism.
MedLine Citation:
PMID:  23969162     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Acute pulmonary embolism (APE) is the third most common cause of death in the United States. Appearing as a sudden blockage in a major pulmonary artery, APE may cause mild, moderate or severe right ventricular (RV) overload. Although severe RV overload produces diagnostically obvious RV mechanical failure, little progress has been made in gaining a clinical and biophysical understanding of moderate and mild acute RV overload and its impact on RV functionality. In the research described here, we conducted a pilot study in pigs using echocardiography and observed the following abnormalities in RV functionality under acute mild or moderate RV overload: (i) occurrence of paradoxical septal motion with "waving" dynamics; (ii) decrease in local curvature of the septum (p < 0.01); (iii) lower positive correlation between movement of the RV free wall and movement of the septum (p < 0.05); (iv) slower rate of RV fractional area change (p < 0.05); and (v) decrease in movement stability, particularly in the middle of the septum (p < 0.05).
Authors:
Nima Tajbakhsh; Hong Wu; Wenzhe Xue; Eileen M McMahon; Marek Belohlavek; Jianming Liang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-8-19
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  -     ISSN:  1879-291X     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-8-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
Affiliation:
Department of Biomedical Informatics, Arizona State University, Scottsdale, Arizona, USA. Electronic address: Nima.Tajbakhsh@asu.edu.
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