Document Detail

Motility, expression of surface antigen, and X and Y human sperm separation in in vitro fertilization medium.
MedLine Citation:
PMID:  6542031     Owner:  NLM     Status:  MEDLINE    
The influence of surrounding medium on human sperm swimming behavior has been characterized. In modified Ham's F-10 serum-supplemented in vitro fertilization medium, the straight-track swimming pattern of sperm in semen changed rapidly into circular tracks, and a new surface antigen was detected soon after this change. The circular tracks alternated between clockwise and counterclockwise directional movements. Addition of 17 beta-estradiol in a concentration range found in follicular fluid increased the frequency of clockwise movement twofold, suggesting that a steep concentration gradient created by an aduterine flow during ovulation, is likely to direct sperm migration up the gradient in the ipsilateral oviduct. Separation of X and Y sperm raised the possibility that a female carrier of an X-linked disease might choose to have a daughter, instead of taking the chance of having an affected son.
S Sarkar
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  42     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-01-17     Completed Date:  1985-01-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  899-905     Citation Subset:  IM    
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MeSH Terms
Antibodies, Monoclonal / immunology
Antigens, Surface / analysis*
Cell Fractionation
Estradiol / pharmacology
Fertilization in Vitro*
Heterozygote Detection
Linkage (Genetics)
Sex Chromosome Aberrations / genetics,  prevention & control
Sperm Motility*
Spermatozoa / classification*,  immunology
X Chromosome
Y Chromosome
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, Surface; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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