| Motilin-independent ectopic fronts of the interdigestive myoelectric complex in dogs. | |
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MedLine Citation:
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PMID: 6108074 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have studied in four conscious dogs the relationship between circulating concentrations of motilin and the activity front (phase III) of the interdigestive myoelectric complex. During fasting, cyclic peaks of motilin secretion were concomitant in every instance with the initiation of activity fronts that began in the stomach or duodenum. When somatostatin was administered at doses of 5, 2.5, or 0.625 microgram x kg-1 x h-1 for 3 h, motilin concentrations were stabilized at lowered levels and no activity fronts occurred in the duodenum. Somatostatin also inhibited the stimulatory effects of exogenous motilin on the entire small intestine. During somatostatin infusion, however, ectopic fronts began in the jejunum and were propagated to the cecum despite low motilin concentration. After a 100-g meat meal, the cyclic increase of motilin was interrupted and no activity fronts were observed in the duodenum, but ectopic fronts started lower in the small intestine. Our study supports the hypothesis that motilin induces activity fronts in the canine duodenum, but it shows that ectopic fronts are not controlled by motilin. |
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Authors:
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P Poitras; J H Steinbach; G VanDeventer; C F Code; J H Walsh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 239 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1980 Sep |
Date Detail:
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Created Date: 1981-01-26 Completed Date: 1981-01-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: G215-20 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Animals Dogs Duodenum / physiology Female Gastrointestinal Hormones / blood* Gastrointestinal Motility* / drug effects Motilin / blood*, pharmacology Somatostatin / pharmacology Stomach / physiology |
| Grant Support | |
ID/Acronym/Agency:
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AM-17328/AM/NIADDK NIH HHS; AM-18618/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Gastrointestinal Hormones; 51110-01-1/Somatostatin; 52906-92-0/Motilin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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