Document Detail

Mother's own milk, donor human milk, and preterm formulas in the feeding of extremely premature infants.
MedLine Citation:
PMID:  18185087     Owner:  NLM     Status:  MEDLINE    
Significant benefits to infant host defense, sensory-neural development, gastrointestinal maturation, and some aspects of nutritional status are observed when premature infants are fed their mothers' own milk. A reduction in infection-related morbidity in human milk-fed premature infants has been reported in nearly 1 dozen descriptive, and a few quasirandomized, studies in the past 25 years. Studies on neurodevelopmental outcomes have reported significantly positive effects for human milk intake on mental and motor development, intelligence quotient, and visual acuity compared with the feeding of formula. Human milk-fed infants also have decreased rates of rehospitalization after discharge. It is unclear how much human milk is needed to provide protection or at what postnatal age the protective effects maximize. The data suggest that a specific dose of milk may be needed to confer protection. A detailed composition analysis of milk obtained from women delivering before 30 weeks of gestation is needed to determine if the "immature" milk contains the same functional bioactive factors as more mature milk. Furthermore, lactation strategies should be sought that increase mother's own milk production.
Richard J Schanler
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  45 Suppl 3     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-01-10     Completed Date:  2008-02-25     Revised Date:  2009-02-12    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S175-7     Citation Subset:  IM    
Division of Neonatal-Perinatal Medicine, Schneider Children's Hospital at North Shore, Manhasset, NY, USA.
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MeSH Terms
Immune System / growth & development,  physiology
Infant Formula*
Infant Nutritional Physiological Phenomena
Infant, Newborn
Infant, Premature* / growth & development,  immunology,  physiology
Milk, Human
Erratum In:
J Pediatr Gastroenterol Nutr. 2009 Jan;48(1):121-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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