| Mother's milk-induced Hsp70 expression preserves intestinal epithelial barrier function in an immature rat pup model. | |
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MedLine Citation:
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PMID: 21263375 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Preterm infants face many challenges in transitioning from the in utero to extrauterine environment while still immature. Failure of the preterm gut to successfully mature to accommodate bacteria and food substrate leads to significant morbidity such as neonatal necrotizing enterocolitis. The intestinal epithelial barrier plays a critical role in gut protection. Heat shock protein 70 (Hsp70) is an inducible cytoprotective molecule shown to protect the intestinal epithelium in adult models. To investigate the hypothesis that Hsp70 may be important for early protection of the immature intestine, Hsp70 expression was evaluated in intestine of immature rat pups. Data demonstrate that Hsp70 is induced by exposure to mother's milk. Hsp70 is found in mother's milk, and increased Hsp70 transcription is induced by mother's milk. This Hsp70 colocalizes with the tight junction protein ZO-1. Mother's milk-induced Hsp70 may contribute to maintenance of barrier function in the face of oxidant stress. Further understanding of the means by which mother's milk increases Hsp70 in the ileum will allow potential means of strengthening the intestinal barrier in at-risk preterm infants. |
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Authors:
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Jennifer L Liedel; Yuee Guo; Yueyue Yu; Sheng-Ru Shiou; Sangzi Chen; Elaine O Petrof; Shien Hu; Mark W Musch; Erika C Claud |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric research Volume: 69 ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-15 Completed Date: 2011-07-25 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 395-400 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, The University of Chicago, Chicago, Illinois 60637, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Anoxia / metabolism Bacterial Infections / metabolism, microbiology Cytoprotection Disease Models, Animal HSP70 Heat-Shock Proteins / genetics, metabolism* Ileum / metabolism*, microbiology, pathology Intestinal Mucosa / metabolism*, microbiology, pathology Membrane Proteins / metabolism Milk / metabolism* Oxidative Stress Permeability Phosphoproteins / metabolism RNA, Messenger / metabolism Rats Tight Junctions / metabolism Up-Regulation |
| Grant Support | |
ID/Acronym/Agency:
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AT 00404/AT/NCCAM NIH HHS; DK42086/DK/NIDDK NIH HHS; F32 HD062144-01A1/HD/NICHD NIH HHS; HD 55237/HD/NICHD NIH HHS; HD 59123/HD/NICHD NIH HHS; K08 HD049514/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/HSP70 Heat-Shock Proteins; 0/Membrane Proteins; 0/Phosphoproteins; 0/RNA, Messenger; 0/zonula occludens-1 protein |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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