Document Detail

Mother-to-infant transmission of hepatitis B virus: A chinese experience.
MedLine Citation:
PMID:  21360547     Owner:  NLM     Status:  Publisher    
Over 90% of infants infected with hepatitis B virus (HBV) caused by mother-to-infant transmission will evolve to carrier status, and this cannot be prevented until widespread administration of the HB vaccine and hepatitis B immune globulin (HBIG) is implemented. This prospective study of 214 infants born to HBsAg-positive mothers was carried out to determine if either perinatal or intrauterine HBV transmission could be effectively prevented with HBIG and the HB vaccine. Peripheral blood was collected from mothers and from newborns before they received HBIG and the HB vaccine, as well as at 0, 1, 7, 24, and 36 months after birth. Infants born with an ratio of signal to noise(S/N) value of >5 for HBsAg (ABBOTT Diagnostic Kit) were defined as mother-to-infant transmission cases, those with an S/N between 5 and 50 were classified as perinatal transmission cases, and those with an S/N >50 were considered intrauterine transmission cases. Mother-to-infant transmission occurred in approximately 4.7% (10/214) of the infants; the perinatal transmission and intrauterine transmission rates were 3.7% (8/214) and 0.9% (2/214), respectively. The risk of mother-to-infant transmission increased along with maternal HBeAg or HBVDNA levels. After 36 months of follow-up, all perinatal cases became HBsAg-negative, whereas all intrauterine transmission cases evolved into carrier status. These results indicate that infants infected via intrauterine transmission cannot be effectively protected by HBIG and HB vaccine. J. Med. Virol. © 2011 Wiley-Liss, Inc.
Zhong-Jun Shao; Lei Zhang; Jian-Qiu Xu; De-Zhong Xu; Ke Men; Jin-Xia Zhang; Heng-Chun Cui; Yong-Ping Yan
Related Documents :
18607817 - Acidemia at birth, related to obstetric characteristics and to oxytocin use, during the...
11406027 - Early volume expansion for prevention of morbidity and mortality in very preterm infants.
19692727 - Maternal drinking water arsenic exposure and perinatal outcomes in inner mongolia, china.
9249267 - Predictability of early atopy by cord blood-ige and parental history.
1130877 - Hepatic portoenterostomy: an assessment of its value in the treatment of biliary atresia.
1925697 - Infant mortality among ethnic immigrant groups.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-25
Journal Detail:
Title:  Journal of medical virology     Volume:  -     ISSN:  1096-9071     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-3-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Department of Epidemiology, School of Public Health, The Fourth Military Medical University, Xi'an, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hantavirus-specific IgA in saliva and viral antigen in the parotid gland in patients with hemorrhagi...
Next Document:  Subtype diversity associated with the development of HIV-1 resistance to integrase inhibitors.