Document Detail

Mother-to-infant transmission of hepatitis C virus: rate of infection and assessment of viral load and IgM anti-HCV as risk factors.
MedLine Citation:
PMID:  11992574     Owner:  NLM     Status:  MEDLINE    
One hundred twenty-six mother-infant couples were studied and 105 exposed babies were monitored for at least 12 months to define the risk of mother-to-infant HCV transmission. Infection occurred in 5 out of 76 infants (6.6%) born to 69 viraemic mothers and in none of 29 born to 26 non-viraemic mothers. Only one child was HCV RNA positive one month after birth, while the remaining children became positive at the 3rd to 4th month. HCV genotypes of the babies matched those of their mothers. No difference was found between women who transmitted the virus and those who did not with regard to age, history of drug abuse, HIV infection, ALT abnormal values, HCV genotype, type of delivery, and breast-feeding. Four out of 5 infected infants were born to mothers with IgM anti-HCV (P = 0.04). The mean viral titre in transmitting women (10(7.2)) was higher than in non-transmitting (10(6.5)), and the proportion of mothers with viral load > or = 10(7) was statistically higher in transmitting than non-transmitting women (P = 0.03). These data show that HCV perinatal infection is a rare event and suggest that IgM positivity and high viral load (> or = 10(7)) in the mother are independent variables correlated with HCV transmission (O.R. = 14.5; 95% CI: 1.3-160.7 and O.R. = 16.3; 95% CI: 1.5-179.9, respectively).
Gianna Dal Molin; Pierlanfranco D'Agaro; Filippo Ansaldi; Giovanni Ciana; Cristina Fertz; Salvatore Alberico; Cesare Campello
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medical virology     Volume:  67     ISSN:  0146-6615     ISO Abbreviation:  J. Med. Virol.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-05-23     Completed Date:  2002-07-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7705876     Medline TA:  J Med Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  137-42     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
Department of Public Medicine Sciences, U.C.O. Hygiene and Preventive Medicine, University of Trieste and IRCCS Burlo Garofolo, Trieste, Italy.
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MeSH Terms
Hepacivirus / immunology*,  isolation & purification*
Hepatitis C / epidemiology,  transmission*,  virology
Hepatitis C Antibodies / blood
Immunoglobulin M / blood
Infant, Newborn
Infectious Disease Transmission, Vertical*
Pregnancy Complications, Infectious / virology*
RNA, Viral / blood
Risk Assessment
Risk Factors
Viral Load
Reg. No./Substance:
0/Hepatitis C Antibodies; 0/Immunoglobulin M; 0/RNA, Viral

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