Document Detail


Mother-to-fetus transfer of antiviral drugs and the involvement of transporters at the placental barrier.
MedLine Citation:
PMID:  21626508     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Administration of antiviral drugs to pregnant women with influenza, human immunodeficiency virus (HIV), and herpes simplex virus (HSV) infections is widely accepted as an effective treatment to safeguard the health of the mother and fetus. This review deals with the transfer of antiviral drugs to the fetus across the placental barrier, which is formed by an epithelial layer of syncytiotrophoblasts. First, the structure, function, and developmental change of the placenta and the placental barrier are briefly presented. We then review the transplacental permeability of antiviral drugs, such as oseltamivir for influenza, antiretrovirals (e.g., zidovudine, didanosine, and saquinavir) for HIV, and acyclovir for HSV, focusing on the involvement of ATP-binding cassette, organic anion/cation, and nucleoside transporters. The increasing evidence that is becoming available about transport mechanisms operating at the placental barrier is expected to be useful in the development of techniques to control fetal and placental transfer of antiviral drugs, and thereby to obtain maximum therapeutic benefit while minimizing potential fetal toxicity. © 2011 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci.
Authors:
Masatoshi Tomi; Tomohiro Nishimura; Emi Nakashima
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-29
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  -     ISSN:  1520-6017     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Affiliation:
Faculty of Pharmacy, Keio University, Minato-ku, Tokyo 105-8512, Japan. tomi-ms@pha.keio.ac.jp.
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