Document Detail

Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytoma.
MedLine Citation:
PMID:  12640106     Owner:  NLM     Status:  MEDLINE    
Forty-four samples from 25 cases of retroperitoneal sarcoma initially diagnosed as malignant fibrous histiocytoma were histologically reviewed. Immunohistochemistry for mdm2 and cdk4 was performed on 20 cases. Comparative genomic hybridization was performed on 18 samples from 13 patients. Seventeen cases were reclassified as dedifferentiated liposarcoma. Twenty-one of 32 samples from these patients showed areas of well-differentiated liposarcoma, allowing the diagnosis of dedifferentiated liposarcoma. Immunohistochemistry performed in 15 of these cases showed positivity for mdm2 and cdk4. Comparative genomic hybridization analysis performed on 15 samples from 11 of these patients showed an amplification of the 12q13-15 region. Eight cases were reclassified as poorly differentiated sarcoma. Twelve samples from these patients showed no area of well-differentiated liposarcoma. Immunohistochemistry showed positivity for mdm2 and cdk4 in one of six of these patients and showed positivity for CD34 in another one. Comparative genomic hybridization analysis performed on three samples from two of these patients showed no amplification of the 12q13-15 region but showed complex profiles. This study shows that most so-called malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcoma and that a poorly differentiated sarcoma in this area should prompt extensive sampling to demonstrate a well-differentiated liposarcoma component, immunohistochemistry for mdm2 and cdk4, and if possible, a cytogenetic or a molecular biology analysis.
Jean-Michel Coindre; Odette Mariani; Frédéric Chibon; Aline Mairal; Nicolas De Saint Aubain Somerhausen; Elizabeth Favre-Guillevin; Nguyen Binh Bui; Eberhard Stoeckle; Isabelle Hostein; Alain Aurias
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc     Volume:  16     ISSN:  0893-3952     ISO Abbreviation:  Mod. Pathol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-17     Completed Date:  2003-10-14     Revised Date:  2012-06-25    
Medline Journal Info:
Nlm Unique ID:  8806605     Medline TA:  Mod Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  256-62     Citation Subset:  IM    
Department of Pathology, Institut Bergonié, Bordeaux, France.
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MeSH Terms
Aged, 80 and over
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinases / metabolism
Diagnosis, Differential
Gene Amplification
Histiocytoma, Benign Fibrous / genetics,  metabolism,  pathology*
Liposarcoma / genetics,  metabolism,  pathology*
Middle Aged
Nuclear Proteins*
Nucleic Acid Hybridization
Proto-Oncogene Proteins / metabolism
Proto-Oncogene Proteins c-mdm2
Retroperitoneal Neoplasms / genetics,  metabolism,  pathology*
Retrospective Studies
Reg. No./Substance:
0/Nuclear Proteins; 0/Proto-Oncogene Proteins; EC protein, human; EC Kinase 4; EC Kinases; EC protein, human; EC Proteins c-mdm2

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