| Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytoma. | |
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MedLine Citation:
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PMID: 12640106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Forty-four samples from 25 cases of retroperitoneal sarcoma initially diagnosed as malignant fibrous histiocytoma were histologically reviewed. Immunohistochemistry for mdm2 and cdk4 was performed on 20 cases. Comparative genomic hybridization was performed on 18 samples from 13 patients. Seventeen cases were reclassified as dedifferentiated liposarcoma. Twenty-one of 32 samples from these patients showed areas of well-differentiated liposarcoma, allowing the diagnosis of dedifferentiated liposarcoma. Immunohistochemistry performed in 15 of these cases showed positivity for mdm2 and cdk4. Comparative genomic hybridization analysis performed on 15 samples from 11 of these patients showed an amplification of the 12q13-15 region. Eight cases were reclassified as poorly differentiated sarcoma. Twelve samples from these patients showed no area of well-differentiated liposarcoma. Immunohistochemistry showed positivity for mdm2 and cdk4 in one of six of these patients and showed positivity for CD34 in another one. Comparative genomic hybridization analysis performed on three samples from two of these patients showed no amplification of the 12q13-15 region but showed complex profiles. This study shows that most so-called malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcoma and that a poorly differentiated sarcoma in this area should prompt extensive sampling to demonstrate a well-differentiated liposarcoma component, immunohistochemistry for mdm2 and cdk4, and if possible, a cytogenetic or a molecular biology analysis. |
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Authors:
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Jean-Michel Coindre; Odette Mariani; Frédéric Chibon; Aline Mairal; Nicolas De Saint Aubain Somerhausen; Elizabeth Favre-Guillevin; Nguyen Binh Bui; Eberhard Stoeckle; Isabelle Hostein; Alain Aurias |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Volume: 16 ISSN: 0893-3952 ISO Abbreviation: Mod. Pathol. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-03-17 Completed Date: 2003-10-14 Revised Date: 2012-06-25 |
Medline Journal Info:
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Nlm Unique ID: 8806605 Medline TA: Mod Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 256-62 Citation Subset: IM |
Affiliation:
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Department of Pathology, Institut Bergonié, Bordeaux, France. coindre@bergonie.org. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinases / metabolism Diagnosis, Differential Female Gene Amplification Histiocytoma, Benign Fibrous / genetics, metabolism, pathology* Humans Immunohistochemistry Liposarcoma / genetics, metabolism, pathology* Male Middle Aged Nuclear Proteins* Nucleic Acid Hybridization Proto-Oncogene Proteins / metabolism Proto-Oncogene Proteins c-mdm2 Retroperitoneal Neoplasms / genetics, metabolism, pathology* Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Nuclear Proteins; 0/Proto-Oncogene Proteins; EC 2.7.11.22/CDK4 protein, human; EC 2.7.11.22/Cyclin-Dependent Kinase 4; EC 2.7.11.22/Cyclin-Dependent Kinases; EC 6.3.2.19/MDM2 protein, human; EC 6.3.2.19/Proto-Oncogene Proteins c-mdm2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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