Document Detail

Most reported genetic associations with general intelligence are probably false positives.
MedLine Citation:
PMID:  23012269     Owner:  NLM     Status:  MEDLINE    
General intelligence (g) and virtually all other behavioral traits are heritable. Associations between g and specific single-nucleotide polymorphisms (SNPs) in several candidate genes involved in brain function have been reported. We sought to replicate published associations between g and 12 specific genetic variants (in the genes DTNBP1, CTSD, DRD2, ANKK1, CHRM2, SSADH, COMT, BDNF, CHRNA4, DISC1, APOE, and SNAP25) using data sets from three independent, well-characterized longitudinal studies with samples of 5,571, 1,759, and 2,441 individuals. Of 32 independent tests across all three data sets, only 1 was nominally significant. By contrast, power analyses showed that we should have expected 10 to 15 significant associations, given reasonable assumptions for genotype effect sizes. For positive controls, we confirmed accepted genetic associations for Alzheimer's disease and body mass index, and we used SNP-based calculations of genetic relatedness to replicate previous estimates that about half of the variance in g is accounted for by common genetic variation among individuals. We conclude that the molecular genetics of psychology and social science requires approaches that go beyond the examination of candidate genes.
Christopher F Chabris; Benjamin M Hebert; Daniel J Benjamin; Jonathan Beauchamp; David Cesarini; Matthijs van der Loos; Magnus Johannesson; Patrik K E Magnusson; Paul Lichtenstein; Craig S Atwood; Jeremy Freese; Taissa S Hauser; Robert M Hauser; Nicholas Christakis; David Laibson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-09-24
Journal Detail:
Title:  Psychological science     Volume:  23     ISSN:  1467-9280     ISO Abbreviation:  Psychol Sci     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-15     Completed Date:  2013-11-14     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  9007542     Medline TA:  Psychol Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1314-23     Citation Subset:  IM    
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MeSH Terms
Intelligence / genetics*
Polymorphism, Single Nucleotide
Reproducibility of Results
Grant Support
P01 AG005842/AG/NIA NIH HHS; P01 AG005842-20/AG/NIA NIH HHS; P01AG005842/AG/NIA NIH HHS; P30 AG012810/AG/NIA NIH HHS; QLG2-CT-2002-01254/CT/CIT NIH HHS; T32 AG000186/AG/NIA NIH HHS; T32 AG000186-23/AG/NIA NIH HHS; T32-AG000186-23/AG/NIA NIH HHS

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