| Mosaicism of the retinal pigment epithelium: seeing the small picture. | |
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MedLine Citation:
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PMID: 16123538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The retinal pigment epithelium (RPE) is a monolayer of cells that appear phenotypically regular, but which exhibit striking cell-cell variability in content of melanin and lipofuscin granules, and in expression of many proteins. This naturally occurring cell heterogeneity likely arises by normal mechanisms regulating gene expression during development and postnatal aging. The consequence is a tissue in which individual cells may differ in their ability to support adjacent photoreceptors, and which may respond differentially to oxidative stress and other environmental influences that contribute to cell dysfunction during aging. The inherent variability of RPE cells is probably one factor contributing to the characteristically patchy pattern of retinal diseases like age-related macular degeneration. |
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Authors:
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Janice M Burke; Leonard M Hjelmeland |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Molecular interventions Volume: 5 ISSN: 1534-0384 ISO Abbreviation: Mol. Interv. Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-08-26 Completed Date: 2005-10-25 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101093789 Medline TA: Mol Interv Country: United States |
Other Details:
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Languages: eng Pagination: 241-9 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Medical College of Wisconsin, The Eye Institute, 925 N. 87th St., Milwaukee, WI 53226, USA. jburke@mcw.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cells, Cultured Cytoplasmic Granules / chemistry*, metabolism Epigenesis, Genetic Humans Mosaicism* Photoreceptor Cells / cytology, metabolism Pigment Epithelium of Eye* / cytology, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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EY006473/EY/NEI NIH HHS; EY013722/EY/NEI NIH HHS; EY015284/EY/NEI NIH HHS; P30 EY01931/EY/NEI NIH HHS |
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