| Mosaicism in chorionic villus sampling: an analysis of incidence and chromosomes involved in 2612 consecutive cases. | |
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MedLine Citation:
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PMID: 8506219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The incidence of chromosome mosaicism was analysed in 2612 consecutive chorionic villus sampling (CVS) cases. True mosaicism was found in five cases (0.19 per cent). Confined placental mosaicism (CPM) occurred in 51 cases (1.9 per cent). The chromosomes most frequently encountered in CPM were 2, 7, 8, and the sex chromosomes. Three types of CPM as proposed by Kalousek et al. (1992) were observed. Cases with CPM had a statistically significant association with spontaneous abortion (chi 2 = 3.92, p < 0.05). Based on the data analysed, we conclude that (1) CPM is as likely to occur in cultured chorionic villi as in the direct preparation; (2) as with amniocyte culture, chromosome 2 mosaicism occurs commonly in villus culture; (3) the incidence of false-positive results can be greatly reduced and concern about maternal cell contamination can be alleviated by using both direct cytotrophoblast preparation and cultured chorionic stroma cells in all cases; and (4) follow-up cytogenetic and obstetrical studies, such as ultrasound and fetal monitoring, should always be considered in cases where CPM is suspected. |
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Authors:
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B B Wang; C H Rubin; J Williams |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 13 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-07-02 Completed Date: 1993-07-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 179-90 Citation Subset: IM |
Affiliation:
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Prenatal Diagnostic Center of Southern California, Inc., Beverly Hills 90211. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Cells, Cultured
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ultrastructure Chorionic Villi Sampling* / methods Chromosome Aberrations / epidemiology* Chromosome Disorders Chromosomes, Human, Pair 13 Chromosomes, Human, Pair 2 Chromosomes, Human, Pair 7 Chromosomes, Human, Pair 8 False Positive Reactions Female Humans Mosaicism* Pregnancy Pregnancy Outcome Trisomy X Chromosome Y Chromosome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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