Document Detail


Mosaicism in chorionic villus sampling: an association with poor perinatal outcome.
MedLine Citation:
PMID:  2314775     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prenatal diagnosis by first-trimester chorionic villus sampling was successful in 4319 pregnancies involving 4395 fetuses. Cytogenetic information was obtained by both rapid cytotrophoblastic preparation and monolayer mesenchymal tissue culture. Chromosomal mosaicism was present in 55 of 4319 (1.3%). The abnormal cell line involved the cytotrophoblast in 79.6% of the mosaic specimens. None of the abnormalities found in the cytotrophoblast were confirmed in the fetus when the tissue culture was normal, supporting the belief that the cells of the mesenchymal core more truly reflect the chromosomal constitution of the fetus. However, a significant increase in the perinatal loss rate in the placental mosaic group was noted when compared with the nonmosaics: 16.7 versus 2.7% (P = .0001). These findings suggest that placental mosaicism may be a cause of perinatal loss.
Authors:
A Johnson; R J Wapner; G H Davis; L G Jackson
Related Documents :
631095 - A preliminary report about transcervical embryoscopy.
3890545 - Chorionic villus sampling for first-trimester prenatal diagnosis: northwestern universi...
8882465 - Prenatal diagnosis of inherited skin diseases.
1523855 - A spontaneous combined (heterotopic) pregnancy: a case report.
1685165 - Laparoscopic management of tubal pregnancy.
12418075 - Management of gigantomastia complicating pregnancy. a case report.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  75     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-04-26     Completed Date:  1990-04-26     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  573-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / etiology
Chorionic Villi Sampling*
Chromosome Aberrations / diagnosis
Chromosome Disorders
Female
Fetal Death
Fetus / ultrastructure
Humans
Infant Mortality
Karyotyping
Mosaicism*
Placenta / ultrastructure
Pregnancy
Pregnancy Outcome*
Prenatal Diagnosis
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Survey of neurological problems with amiodarone in the New Zealand Intensive Medicines Monitoring Pr...
Next Document:  Acute hypoxemia does not affect the umbilical artery flow velocity waveform in fetal sheep.