Document Detail

Mosaicism in chorionic villus sampling: an association with poor perinatal outcome.
MedLine Citation:
PMID:  2314775     Owner:  NLM     Status:  MEDLINE    
Prenatal diagnosis by first-trimester chorionic villus sampling was successful in 4319 pregnancies involving 4395 fetuses. Cytogenetic information was obtained by both rapid cytotrophoblastic preparation and monolayer mesenchymal tissue culture. Chromosomal mosaicism was present in 55 of 4319 (1.3%). The abnormal cell line involved the cytotrophoblast in 79.6% of the mosaic specimens. None of the abnormalities found in the cytotrophoblast were confirmed in the fetus when the tissue culture was normal, supporting the belief that the cells of the mesenchymal core more truly reflect the chromosomal constitution of the fetus. However, a significant increase in the perinatal loss rate in the placental mosaic group was noted when compared with the nonmosaics: 16.7 versus 2.7% (P = .0001). These findings suggest that placental mosaicism may be a cause of perinatal loss.
A Johnson; R J Wapner; G H Davis; L G Jackson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  75     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-04-26     Completed Date:  1990-04-26     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  573-7     Citation Subset:  AIM; IM    
Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania.
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MeSH Terms
Abortion, Spontaneous / etiology
Chorionic Villi Sampling*
Chromosome Aberrations / diagnosis
Chromosome Disorders
Fetal Death
Fetus / ultrastructure
Infant Mortality
Placenta / ultrastructure
Pregnancy Outcome*
Prenatal Diagnosis
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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