| Mosaic ring chromosome 21, monosomy 21, and isodicentric ring chromosome 21: prenatal diagnosis, molecular cytogenetic characterization, and association with 2-Mb deletion of 21q21.1-q21.2 and 5-Mb deletion of 21q22.3. | |
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MedLine Citation:
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PMID: 22482972 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To present the perinatal findings and molecular cytogenetic characterization of prenatally detected mosaic r(21). MATERIALS, METHODS, AND RESULTS: A 29-year-old primigravid woman underwent amniocentesis at 22 weeks' gestation because of hyperechogenic cardiac foci and intrauterine growth restriction. Amniocentesis revealed a karyotype of 46,XY,r(21)[15]/45,XY,-21[5]. The parental karyotypes were normal. The woman requested repeat amniocentesis. Oligonucleotide-based array comparative genomic hybridization was applied to the uncultured amniocytes, rapidly detecting a 2.09-Mb deletion of 21q21.1-q21.2 (21,495,262-23,580,815 bp) and a 5.03-Mb deletion of 21q22.3-q22.3 (41,887,412-46,914,715 bp). Cytogenetic analysis revealed a karyotype of 46,XY,r(21)[8]/45,XY,-21[3]/46,XY,idic r(21)[1]. The pregnancy was terminated, and a malformed fetus was delivered with clinodactyly, short big toes, separation between the first and second toes, prominent nasal bridge, downward slanting palpebral fissures, protuberant occiput, prominent forehead, broad anteverted nasal tip, long philtrum, thin upper lip, small mouth, and micrognathia. The placenta had a karyotype of 46,XY,r(21)[83]/45,XY,-21[11]/46,XY,idic r(21)[6], and the cord blood lymphocytes had a karyotype of 46,XY,r(21)[88]/45,XY,-21[9]/46,XY,idic r(21)[3]. Polymorphic DNA marker analysis determined a maternal origin for the deletion. CONCLUSION: An extra interstitial 21q deletion can be associated with mosaic r(21) in addition to a terminal 21q deletion. aCGH is useful in determining the breakpoints and associated subtle structural abnormalities in cases of prenatally detected ring chromosome in order to facilitate genetic counseling. |
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Authors:
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Chih-Ping Chen; Yi-Hui Lin; Szu-Yuan Chou; Yi-Ning Su; Schu-Rern Chern; Yu-Ting Chen; Dai-Dyi Town; Wen-Lin Chen; Wayseen Wang |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Taiwanese journal of obstetrics & gynecology Volume: 51 ISSN: 1875-6263 ISO Abbreviation: Taiwan J Obstet Gynecol Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-04-09 Completed Date: 2012-08-27 Revised Date: 2012-09-10 |
Medline Journal Info:
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Nlm Unique ID: 101213819 Medline TA: Taiwan J Obstet Gynecol Country: China |
Other Details:
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Languages: eng Pagination: 71-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2012. Published by Elsevier B.V. |
Affiliation:
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Department of Medicine, Mackay Medical College, New Taipei City, Taiwan. cpc_mmh@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple
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genetics*,
ultrasonography Adult Base Sequence / genetics* Chromosomes, Human, Pair 21* Female Fetal Diseases / genetics*, ultrasonography Genetic Testing Humans Karyotype Monosomy / diagnosis Pregnancy Prenatal Diagnosis* Ring Chromosomes Sequence Deletion / genetics* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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