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Mosaic copy number variation in schizophrenia.
MedLine Citation:
PMID:  23321615     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Recent reports suggest that somatic structural changes occur in the human genome, but how these genomic alterations might contribute to disease is unknown. Using samples collected as part of the International Schizophrenia Consortium (schizophrenia, n=3518; control, n=4238) recruited across multiple university research centers, we assessed single-nucleotide polymorphism genotyping arrays for evidence of chromosomal anomalies. Data from genotyping arrays on each individual were processed using Birdsuite and analyzed with PLINK. We validated potential chromosomal anomalies using custom nanostring probes and quantitative PCR. We estimate chromosomal alterations in the schizophrenia population to be 0.42%, which is not significantly different from controls (0.26%). We identified and validated a set of four extremely large (>10 Mb) chromosomal anomalies in subjects with schizophrenia, including a chromosome 8 trisomy and deletion of the q arm of chromosome 7. These data demonstrate that chromosomal anomalies are present at low frequency in blood cells of both control and schizophrenia subjects.European Journal of Human Genetics advance online publication, 16 January 2013; doi:10.1038/ejhg.2012.287.
Authors:
Douglas M Ruderfer; Kim Chambert; Jennifer Moran; Michael Talkowski; Elizabeth S Chen; Carolina Gigek; James F Gusella; Douglas H Blackwood; Aiden Corvin; Hugh M Gurling; Christina M Hultman; George Kirov; Patrick Magnusson; Michael C O'Donovan; Michael J Owen; Carlos Pato; David St Clair; Patrick F Sullivan; Shaun M Purcell; Pamela Sklar; Carl Ernst
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-16
Journal Detail:
Title:  European journal of human genetics : EJHG     Volume:  -     ISSN:  1476-5438     ISO Abbreviation:  Eur. J. Hum. Genet.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9302235     Medline TA:  Eur J Hum Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1] Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA [2] Division of Psychiatric Genomics, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA [3] Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
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