Document Detail


The mosaic theory revisited: common molecular mechanisms coordinating diverse organ and cellular events in hypertension.
MedLine Citation:
PMID:  23321405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
More than 60 years ago, Dr. Irvine Page proposed the Mosaic Theory of hypertension, which states that many factors, including genetics, environment, adaptive, neural, mechanical, and hormonal perturbations interdigitate to raise blood pressure. In the past two decades, it has become clear that common molecular and cellular events in various organs underlie many features of the Mosaic Theory. Two of these are the production of reactive oxygen species and inflammation. These factors increase neuronal firing in specific brain centers, increase sympathetic outflow, alter vascular tone and morphology, and promote sodium retention in the kidney. Moreover, factors such as genetics and environment contribute to oxidant generation and inflammation. Other common cellular signals, including calcium signaling and endoplasmic reticulum stress are similarly perturbed in different cells in hypertension and contribute to components of Page's theory. Thus, Page's Mosaic Theory formed a framework for future studies of molecular and cellular signals in the context of hypertension, and has greatly aided our understanding of this complex disease.
Authors:
David G Harrison
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Journal of the American Society of Hypertension : JASH     Volume:  7     ISSN:  1878-7436     ISO Abbreviation:  J Am Soc Hypertens     Publication Date:    2013 Jan-Feb
Date Detail:
Created Date:  2013-01-16     Completed Date:  2013-07-09     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  101312518     Medline TA:  J Am Soc Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  68-74     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Society of Hypertension. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Hypertension* / immunology,  metabolism,  physiopathology
Inflammation* / immunology,  metabolism,  physiopathology
Oxidative Stress / physiology*
T-Lymphocytes / immunology
Grant Support
ID/Acronym/Agency:
P01 GM015431/GM/NIGMS NIH HHS; P01 HL058000/HL/NHLBI NIH HHS; P01 HL095070/HL/NHLBI NIH HHS; P01GM015431/GM/NIGMS NIH HHS; P01HL058000/HL/NHLBI NIH HHS; P01HL095070/HL/NHLBI NIH HHS; R01 HL039006/HL/NHLBI NIH HHS; R01 HL105294/HL/NHLBI NIH HHS; R01HL039006/HL/NHLBI NIH HHS; R01HL105294-02/HL/NHLBI NIH HHS
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