Document Detail

Morton's neuroma--pathogenesis and ultrastructure.
MedLine Citation:
PMID:  477115     Owner:  NLM     Status:  MEDLINE    
In an attempt to clarify the pathogenesis of Morton's neuroma, 106 documented cases were analyzed by multiple staining techniques and electron microscopy. The lesion was found to consist of a progressive fibrosis which enveloped and disrupted nerves and arteries. No evidence of a nerve proliferation nor of a specific inflammatory process was encountered. Based on these observations, it is concluded that repeated trauma in the connective tissue elements, including nerves and arteries in the interdigital clefts, lead to a reactive overgrowth of connective tissue (scarring) that disrupts the nerves and the arteries. Sclerosis of the arteries and the narrowing of their lumen contributes to ischemia and further nerve atrophy. The nerves and arteries caught in this reactive scar become more sensitive to pressure and cause characteristic pain.
G B Ha'Eri; V L Fornasier; J Schatzker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  -     ISSN:  0009-921X     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:  1979 Jun 
Date Detail:
Created Date:  1979-11-21     Completed Date:  1979-11-21     Revised Date:  2005-03-03    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  256-9     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Vessels / pathology
Connective Tissue / pathology
Metatarsophalangeal Joint / blood supply,  innervation
Metatarsus / blood supply,  innervation*
Middle Aged
Nerve Fibers / pathology,  ultrastructure
Neuralgia / pathology*
Neuroma / pathology*,  ultrastructure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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