Document Detail

Mortality with dementia: results from a French prospective community-based cohort.
MedLine Citation:
PMID:  11581098     Owner:  NLM     Status:  MEDLINE    
Despite the magnitude of the problem, little is known about the duration of dementia. Survival and risk factors of mortality with dementia and the impact of dementia on the risk of death were investigated using the Personnes Agées Quid (PAQUID) prospective population-based cohort study between 1988 and 1998. Statistical models dealing with interval censoring were performed. Among 3,675 participants aged 65 years or older and initially nondemented, 2,923 have been followed up for 8 years. Of these, 281 persons with incident dementia were actively diagnosed. The mean age of onset of dementia was 82.3 years. In the total population, the relative risk of dying after developing dementia was estimated to be 1.82 (95% confidence interval (CI): 1.77, 2.68) when adjusted for sociodemographic variables and comorbidity. Deaths from cerebrovascular diseases and respiratory diseases were particularly increased among persons with dementia, compared with those without. The median survival time of the persons with dementia was estimated to be 4.5 years. Women with dementia had a longer survival than did men with dementia, particularly for Alzheimer-type dementia (relative risk = 0.47, 95% CI: 0.27, 0.83). Educational level was not significantly associated with survival in persons with dementia. These results provide further evidence of the malignancy of dementia, which will be a challenge for the 21st century.
C Helmer; P Joly; L Letenneur; D Commenges; J F Dartigues
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of epidemiology     Volume:  154     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-02     Completed Date:  2001-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  642-8     Citation Subset:  IM    
INSERM U 330, Université de Bordeaux II, Bordeaux, France.
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MeSH Terms
Age of Onset
Aged, 80 and over
Cohort Studies
Dementia / mortality*
Educational Status
France / epidemiology
Proportional Hazards Models
Prospective Studies
Risk Factors
Survival Analysis
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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