Document Detail

Mortality of twins and singletons by gestational age: a varying-coefficient approach.
MedLine Citation:
PMID:  11130615     Owner:  NLM     Status:  MEDLINE    
This study used data from the Swedish Medical Birth Registry between 1982 and 1995 to address the question of whether there is higher mortality in twins in relation to singletons of the same gestational age and to examine the optimal gestational age range for twins. A "varying-coefficient approach" was adopted to estimate the gestational age-specific relative and absolute risks of mortality in twins and singletons, adjusting for size at birth and risk factors of short gestational duration. The models showed that twins born between 29 and 37 weeks of gestation had lower mortality than did singletons of the same gestational age. Twins born at older gestational age had higher mortality than did their singleton counterparts, because longer gestational duration was more advantageous to singletons than to twins. Without adjustment for size at birth, there was an upturn of mortality in twins born after 38 weeks. It is postulated that twins have better health than singletons initially, but they could not enjoy the benefit of a longer gestational duration as much as singletons could. The optimal gestational age for twins appeared to be 37-39 weeks according to neonatal and infant mortality.
Y B Cheung; P Yip; J Karlberg
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of epidemiology     Volume:  152     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-27     Completed Date:  2001-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1107-16     Citation Subset:  IM    
Clinical Trials Centre, Faculty of Medicine, University of Hong Kong, Pokfulam, China.
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MeSH Terms
Age Distribution
Cause of Death*
Gestational Age
Infant Mortality / trends*
Infant, Newborn
Logistic Models
Multivariate Analysis
Risk Factors
Statistics, Nonparametric
Sweden / epidemiology
Comment In:
Am J Epidemiol. 2000 Dec 15;152(12):1117-9; discussion 1120   [PMID:  11130616 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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