| Mortality, severe respiratory distress syndrome, and chronic lung disease of the newborn are reduced more after prophylactic than after therapeutic administration of the surfactant Curosurf. | |
| | |
MedLine Citation:
|
PMID: 9200378 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To test the hypothesis that prophylactic treatment with the surfactant Curosurf (Chiesi Farmaceutici SPA, Parma, Italy) improves survival and respiratory problems more than rescue treatment. DESIGN: Meta-analysis of three prophylaxis versus rescue treatment trials, conducted in four countries. METHODS: A meta-analysis was performed with the original, individual data of mortality, severe respiratory distress syndrome, and chronic lung disease of 671 newborns as outcomes. The random-effects logistic model (accounting for the trial-within-country structure) was applied and adjusted for imbalances in covariates. RESULTS: The probability of each outcome differed between the countries, but the actual treatment effect itself did not. The adjusted odds ratios (ORs) and confidence intervals (CIs) for prophylaxis versus rescue were as follows: mortality: OR, .47; 95% CI, .30 to .73; severe RDS: OR, .50; 95% CI, .33 to .74; and chronic lung disease of the newborn in the survivors at day 28 after birth: OR, .54; 95% CI, .34 to .86. Gender, birth weight, gestational age, and prenatal administration of glucocorticosteroids were significant confounding covariates. CONCLUSION: The analysis shows that for the porcine surfactant Curosurf, prophylactic administration of surfactant has significant advantages over rescue therapy. |
| | |
Authors:
|
J Egberts; R Brand; H Walti; G Bevilacqua; G Bréart; F Gardini |
Related Documents
:
|
10920148 - Neonatal sepsis workups in infants >/=2000 grams at birth: a population-based study. 14643628 - Risk factors for overall and persistent diarrhoea in infancy in antalya, turkey: a coho... 11406028 - Early volume expansion versus inotrope for prevention of morbidity and mortality in ver... 1476148 - Maternal age as a risk factor for wheezing lower respiratory illnesses in the first yea... 2335018 - Crying, feeding and sleeping patterns in 1 to 12-month-old infants. 704198 - Neonatal neurobehavior in the first 48 hours of life: effect of the administration of m... |
Publication Detail:
|
Type: Journal Article; Meta-Analysis |
Journal Detail:
|
Title: Pediatrics Volume: 100 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 1997 Jul |
Date Detail:
|
Created Date: 1998-09-11 Completed Date: 1998-09-11 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: E4 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, University of Leiden, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biological Products* Chronic Disease Clinical Trials as Topic Confounding Factors (Epidemiology) Drug Administration Schedule Female Humans Infant, Newborn Logistic Models Lung Diseases / mortality, prevention & control Male Odds Ratio Phospholipids* Pulmonary Surfactants / administration & dosage* Random Allocation Respiratory Distress Syndrome, Newborn / mortality*, prevention & control* Sex Characteristics Survival Rate Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Biological Products; 0/Phospholipids; 0/Pulmonary Surfactants; 129069-19-8/poractant alfa |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Omeprazole-based dual and triple regimens for Helicobacter pylori eradication in children.
Next Document: Neurodevelopmental outcomes of Ugandan infants with human immunodeficiency virus type 1 infection.