Document Detail


Mortality rates from multiple sclerosis: geographical and temporal variations revisited.
MedLine Citation:
PMID:  2019834     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A review of the United Kingdom (UK) multiple sclerosis (MS) literature suggests that over the last three decades prevalence and estimated incidence rates have increased, while mortality rates have been declining. UK mortality data over a 30 year period have been studied to examine temporal and geographical variations, to estimate changes in survival, and to examine the relationship between mortality and morbidity trends. The study has shown an overall decline in mortality throughout the UK of approximately 25% over the 30 year period ending in 1983, and a reduction in the mortality differential between Scotland, and England and Wales, but no positive correlation has been found between mortality and morbidity. The overall decline in death rate in females was 23% and in males 30% over the 30 years of the survey. The total number of deaths declined by 39% between the five year periods 1954-58 and 1979-83 in Scotland compared with a 10% decline for England and Wales. Estimated median age of death increased from 52 to 59 years and the improvement in survival over the period of study was similar for both countries and is unlikely to have contributed to the reduction in mortality differential. Within England and Wales regional mortality rates did not show a clear north-south gradient. The decline in the mortality differential between Scotland and England (if not artefactual) may provide an important aetiological clue in the search for the cause of multiple sclerosis, and the rate of decline suggests an environmental rather than a genetic aetiology.
Authors:
E S Williams; D R Jones; R O McKeran
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  54     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-05-24     Completed Date:  1991-05-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  104-9     Citation Subset:  IM    
Affiliation:
Department of Public Health Medicine, Croydon General Hospital, UK.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Climate*
Cross-Sectional Studies
Female
Great Britain / epidemiology
Humans
Incidence
Male
Middle Aged
Multiple Sclerosis / mortality*
Risk Factors
Seasons
Comments/Corrections

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