Document Detail

Mortality rates among workers exposed to dioxins in the manufacture of pentachlorophenol.
MedLine Citation:
PMID:  19786897     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We sought to determine if workers exposed to dioxins in pentachlorophenol (PCP) manufacturing were at increased risk of death from specific causes. METHODS: We examined death rates among 773 workers exposed to chlorinated dioxins during PCP manufacturing from 1937 to 1980 using serum dioxin evaluations to estimate exposures to five dioxins. RESULTS: Deaths from all causes combined, all cancers combined, lung cancer, diabetes, and ischemic heart disease were near expected levels. There were eight deaths from non-Hodgkin lymphoma (standardized mortality ratios = 2.4, 95% CI = 1.0 to 4.8). We observed no trend of increasing risk for any cause of death with increasing dioxin exposure. However, the highest rates of non-Hodgkin lymphoma were found in the highest exposure group (standardized mortality ratios = 4.5, 95% CI = 1.2 to 11.5). CONCLUSIONS: Other than possibly an increased risk of non-Hodgkin lymphoma, we find no other cause of death related to the mixture of the dioxin contaminants found in PCP.
James J Collins; Kenneth Bodner; Lesa L Aylward; Michael Wilken; Gerard Swaen; Robert Budinsky; Craig Rowlands; Catherine M Bodnar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine     Volume:  51     ISSN:  1536-5948     ISO Abbreviation:  J. Occup. Environ. Med.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-12     Completed Date:  2010-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504688     Medline TA:  J Occup Environ Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1212-9     Citation Subset:  IM    
The Dow Chemical Company, Midland, Michigan 48674, USA.
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MeSH Terms
Chemical Industry*
Dioxins / adverse effects*,  blood
Environmental Monitoring
Follow-Up Studies
Lymphoma, Non-Hodgkin / etiology,  mortality*
Michigan / epidemiology
Middle Aged
Occupational Exposure / adverse effects*,  analysis
Pentachlorophenol / chemical synthesis
Reg. No./Substance:
0/Dioxins; 87-86-5/Pentachlorophenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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